Evidence map›Paper›PMID 33550104›Full record

SynthesisThe American journal of emergency medicine2021

Intubation rate of patients with hypoxia due to COVID-19 treated with awake proning: A meta-analysis.

Stephanie Cardona, Jessica Downing, Reem Alfalasi, Vera Bzhilyanskaya, David Milzman, Mehboob Rehan, Bradford Schwartz, Isha Yardi, Fariba Yazdanpanah, Quincy K Tran

2 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 7 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05178212 completednot on this map

Characteristics and Outcomes of Patients With COVID-19-related Acute Respiratory Failure Treated With High-flow Nasal Oxygen and Awake-prone Position

Typeobservational_patient_registrySponsorHospital Privado de Comunidad de Mar del PlataRan2020 to 2022Enrolled600ConditionsCOVID-19, Respiratory Failure, Prone Position, Endotracheal Intubation
NCT05957588 nacompletednot on this map

Non-ventilated Prone Positioning in the COVID-19 Population

TypeinterventionalSponsorBaylor St. Luke's Medical CenterRan2021 to 2022Enrolled216ConditionsCOVID-19, Proning, Oxygenation, Length of StayArmsProning group, Control group
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  8. Article
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  13. Awake Prone Decubitus Positioning in COVID-19 Patients: A Systematic Review and MetaAnalysis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023
    Article
  14. Review
  15. Article
  16. COVID-19 Critical Illness: A Data-Driven Review.Annual review of medicine · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. The timing of intubation and principles of ICU care in COVID-19Turkish journal of medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Stephanie CardonaDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: scardona@som.umaryland.edu.
Jessica DowningDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Reem AlfalasiDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Vera BzhilyanskayaResearch Associate Program in Emergency Medicine and Critical Care, The Critical Care Resuscitation Unit, University of Maryland School of Medicine, Baltimore, MD, USA.
David MilzmanDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Mehboob RehanDepartment of Medicine, Eastern Idaho Regional Medical Center, Idaho Falls, ID, USA.
Bradford SchwartzDepartment of Emergency Medicine, Prince George's Hospital Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Isha YardiResearch Associate Program in Emergency Medicine and Critical Care, The Critical Care Resuscitation Unit, University of Maryland School of Medicine, Baltimore, MD, USA.
Fariba YazdanpanahDepartment of Medicine, University of Maryland Capital Region Health, Prince George's Hospital Center, Cheverly, MD, USA.
Quincy K TranDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Research Associate Program in Emergency Medicine and Critical Care, The Critical Care Resuscitation Unit, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Trauma, The R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: qtran@som.umaryland.edu.
University of Maryland, Baltimore · USPrince George's Hospital Center · USRegional Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAwake prone positioning (PP), or proning, is used to avoid intubations in hypoxic patients with COVID-19, but because of the disease's novelty and constant evolution of treatment strategies, the efficacy of awake PP is unclear. We conducted a meta-analysis of the literature to assess the intubation rate among patients with COVID-19 requiring oxygen or noninvasive ventilatory support who underwent awake PP.

methodsWe searched PubMed, Embase, and Scopus databases through August 15, 2020 to identify relevant randomized control trials, observational studies, and case series. We performed random-effects meta-analyses for the primary outcome of intubation rate. We used moderator analysis and meta-regressions to assess sources of heterogeneity. We used the standard and modified Newcastle-Ottawa Scales (NOS) to assess studies' quality.

resultsOur search identified 1043 articles. We included 16 studies from the original search and 2 in-press as of October 2020 in our analysis. All were observational studies. Our analysis included 364 patients; mean age was 56.8 (SD 7.12) years, and 68% were men. The intubation rate was 28% (95% CI 20%-38%, I

conclusionsOur study demonstrated an intubation rate of 28% among hypoxic patients with COVID-19 who underwent awake PP. Awake PP in COVID-19 is feasible and practical, and more rigorous research is needed to confirm this promising intervention.

Indexed as

PandemicsProne PositionWakefulnessCOVID-19HumansIntubation, IntratrachealRespiratory InsufficiencyAwake ProningCoronavirusCOVID-19IntubationNoninvasive ventilationProne positioning

Identifiers

PMID33550104
PMCPMC7839795
OpenAlexW3126605800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.