Evidence map›Paper›PMID 33549925›Full record

ArticlePlacenta2021

Magnetic resonance imaging of placentome development in the pregnant Ewe.

Dimitra Flouri, Jack R T Darby, Stacey L Holman, Sunthara R Perumal, Anna L David, Janna L Morrison, Andrew Melbourne

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Developments in functional imaging of the placenta.The British journal of radiology · 2023
    Review
  7. Advanced imaging of fetal cardiac function.Frontiers in cardiovascular medicine · 2023
    Review
  8. Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Dimitra FlouriSchool of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom. Electronic address: dimitra.flouri@kcl.ac.uk.
Jack R T DarbyEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
Stacey L HolmanEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
Sunthara R PerumalSouth Australian Health & Medical Research Institute, Preclinical, Imaging & Research Laboratories, Adelaide, Australia.
Anna L DavidElizabeth Garrett Anderson Institute for Women's Health, University College London, London, London, United Kingdom; NIHR Biomedical Research Centre, University College London Hospitals, London, United Kingdom.
Janna L MorrisonEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
Andrew MelbourneSchool of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom; Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom; Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
University of South Australia · AUKing's College London · GBSouth Australian Health and Medical Research Institute · AUUniversity College Hospital · GB

Funding

Wellcome Trust 101957Wellcome Trust 101957/Z/13/ZWellcome Trust 203148Wellcome Trust 203148/Z/16/ZWellcome Trust 210182Wellcome Trust 210182/Z/18/Z
6 · The paper itself

Abstract

introductionNovel imaging measurements of placental development are difficult to validate due to the invasive nature of gold-standard procedures. Animal studies have been important in validation of magnetic resonance imaging (MRI) measurements in invasive preclinical studies, as they allow for controlled experiments and analysis of multiple time-points during pregnancy. This study characterises the longitudinal diffusion and perfusion properties of sheep placentomes using MRI, measurements that are required for future validation studies.

methodsPregnant ewes were anaesthetised for a MRI session on a 3T scanner. Placental MRI was used to classify placentomes morphologically into three types based on their shape and size at two gestational ages. To validate classification accuracy, placentome type derived from MRI data were compared with placentome categorisation results after delivery. Diffusion-Weighted MRI and T2-relaxometry were used to measure a broad range of biophysical properties of the placentomes.

resultsMRI morphological classification results showed consistent gestational age changes in placentome shape, as supported by post-delivery gold standard data. The mean apparent diffusion coefficient was significantly higher at 110 days gestation than at late gestation (~140 days; term, 150 days). Mean T2 was higher at mid gestation (152.2 ± 58.1 ms) compared to late gestation (127.8 ms ± 52.0). Significantly higher perfusion fraction was measured in late gestation placentomes that also had a significantly higher fractional anisotropy when compared to the earlier gestational age. DISCUSSION: We report baseline measurements of techniques common in placental MRI for the sheep placenta. These measurements are essential to support future validation measurements of placental MRI techniques.

Indexed as

AnimalsDiffusion Magnetic Resonance ImagingFemaleMagnetic Resonance ImagingPlacentaPlacentationPregnancySheepUterusAnisotropyDiffusionIVIMPlacentaRelaxometry

Identifiers

PMID33549925
PMCPMC7611430
OpenAlexW3124704917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.