Evidence map›Paper›PMID 33549875›Full record

Observational studyJournal of pharmaceutical and biomedical analysis2021

Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding.

Yaru Xing, Bing Zhao, Lin Yin, Mingquan Guo, Huichun Shi, Zhaoqin Zhu, Lin Zhang, Juan He, Yun Ling, Menglu Gao and 3 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pharmaceutical and biomedical analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yaru XingShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Bing ZhaoRuijin Hospital, Jiaotong University, Shanghai 200025, China.
Lin YinShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Mingquan GuoShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Huichun ShiShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Zhaoqin ZhuShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Lin ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Juan HeRuijin Hospital, Jiaotong University, Shanghai 200025, China.
Yun LingShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Menglu GaoShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Hongzhou LuShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China. Electronic address: luhongzhou@fudan.edu.cn.
Enqiang MaoRuijin Hospital, Jiaotong University, Shanghai 200025, China. Electronic address: maoeq@yeah.net.
Lijun ZhangShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China. Electronic address: zhanglijun1221@163.com.
Shanghai Public Health Clinical Center · CNRuijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To administer vitamin C (VC) with precision to patients with the coronavirus disease (COVID-19), we developed an ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to assess plasma VC concentrations. 31 patients with COVID-19 and 51 healthy volunteers were enrolled. VC stability was evaluated in blood, plasma, and precipitant-containing stabilizers. A proportion of 7.7 % of VC was degraded in blood at room temperature (RT) (approximately 20-25 °C) at 1.5 h post administration with respect to the proportion degraded at 0.5 h, but without statistical difference. VC was stable in plasma for 0.75 h at RT, 2 h at 4 °C, 5 days at -40 °C, and 4 h in precipitant-containing stabilizer (2 % oxalic acid) at RT. The mean plasma concentration of VC in patients with COVID-19 was 2.00 mg/L (0.5-4.90) (n = 8), which was almost 5-fold lower than that in healthy volunteers (9.23 mg/L (3.09. 35.30)) (n = 51). After high-dose VC treatment, the mean VC concentration increased to 13.46 mg/L (3.93. 34.70) (n = 36), higher than that in healthy volunteers, and was within the normal range (6-20 mg/L). In summary, we developed a simple UPLC-MS/MS method to quantify VC in plasma, and determined the duration for which the sample remained stable. VC levels in patients with COVID-19 were considerably low, and supplementation at 100 mg/kg/day is considered highly essential.

Indexed as

AdultAgedAscorbic AcidChromatography, High Pressure LiquidCOVID-19Dietary SupplementsFemaleHumansMaleMiddle AgedPlasmaReference ValuesSARS-CoV-2Tandem Mass SpectrometryYoung AdultAscorbic AcidCOVID-19Oxalic acidStabilityUPLC-MS/MSVitamin C

Identifiers

PMID33549875
PMCPMC7839397
OpenAlexW3123579495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.