ArticleActa biomaterialia2021
Mechanically tuned vascular graft demonstrates rapid endothelialization and integration into the porcine iliac artery wall.
Article in Acta biomaterialia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Revisiting the tension-free paradigm: Axially prestretched elastomeric nanofibrillar grafts restore artery-like axial biomechanics in a preclinical model.Acta biomaterialia · 2026Article
- Heparinized Elastomeric Nanofibrillar Grafts: Mechanically Tunable, Cell-Supportive, and Thromboresistant Vascular Substitutes.ACS applied bio materials · 2026Article
- Stent-graft compliance modulates regional mechanical and structural remodeling of the aorta.Acta biomaterialia · 2026Article
- Windkessel Preserving Aortic Stent Graft Attenuates Left Ventricular Remodelling after Thoracic Endovascular Aortic Repair in a Porcine Model.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2026Article
- Effect of stent-graft length and compliance on aortic hemodynamics in a bench-top physiological flow circuit.Journal of the mechanical behavior of biomedical materials · 2026Article
- Heparinized Elastomeric Nanofibrillar Grafts: A Novel Approach for Mechanically Tunable, Cell-Supportive, and Thromboresistant Vascular Substitutes.bioRxiv : the preprint server for biology · 2026Article
- Effect of stent-graft compliance on hemodynamics and aortic stiffening in an in vivo porcine study.Acta biomaterialia · 2026Article
- Fabrication of polymer blend vascular grafts with enhanced mechanical properties and rapid cell infiltration: influence of micro/nanostructure, polymer composition, and post-processing on pore architecture and bioengineered environment.Biomedical materials (Bristol, England) · 2025Article
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Bioprinting Vascularized Constructs for Clinical Relevance: Engineering Hydrogel Systems for Biological Maturity.Gels (Basel, Switzerland) · 2025Review
- Small-Diameter Blood Vessel Substitutes: Biomimetic Approaches to Improve Patency.Biomimetics (Basel, Switzerland) · 2024Review
- The Influence of Textile Structure Characteristics on the Performance of Artificial Blood Vessels.Polymers · 2023Review
- Progress in the application of patch materials in cardiovascular surgery.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Enhancing bioactivity and stability of polymer-based material-tissue interface through coupling multiscale interfacial interactions with atomic-thin TiONano research · 2023Article
- Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta.Journal of functional biomaterials · 2022Article
- Review
- A Computational Framework Examining the Mechanical Behaviour of Bare and Polymer-Covered Self-Expanding Laser-Cut Stents.Cardiovascular engineering and technology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Mechanical properties of vascular grafts likely play important roles in healing and tissue regeneration. Healthy arteries are compliant at low pressures but stiffen rapidly with increasing load, ensuring sufficient volumetric expansion without overstretching the vessel. Commercial synthetic vascular grafts are stiff and unable to expand under physiologic loads, which may result in altered hemodynamics, deleterious cellular responses, and compromised clinical performance. The goal of this study was to develop an Elastomeric Nanofibrillar Graft (ENG) with artery-tuned nonlinear compliance and compare its healing responses to conventional expanded polytetrafluoroethylene (ePTFE) grafts in a porcine iliac artery model. Human and porcine iliac arteries were mechanically characterized, and an ENG with similar properties was created by utilizing residual strains within electrospun nanofibers. The ENG was tested for implantation suitability and implanted onto n = 5 domestic swine iliac arteries, with control ePTFE grafts implanted onto the contralateral iliac arteries. After two weeks in vivo, all iliac arteries and grafts remained patent with no signs of thrombosis or dilation. The mechanically tuned ENG implants exhibited a more confluent CD31-positive cell monolayer (1.53 ± 0.73 µm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.