ArticleNeuroImage2021
Propagating patterns of intrinsic activity along macroscale gradients coordinate functional connections across the whole brain.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 83 citations in OpenAlex.
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- Geometry of neural dynamics along the cortical attractor landscape reflects changes in attention.Nature communications · 2026Article
- Sensory encoding and memory retrieval are coordinated with propagating waves in the human brain.Nature communications · 2026Article
- Connectomes across temporal scales with simultaneous wide-field optical imaging and resting-state functional MRI.bioRxiv : the preprint server for biology · 2026Article
- Global brain activity links subcortical degeneration to cortical tau progressively across Braak regions over early Alzheimer's disease stages.bioRxiv : the preprint server for biology · 2026Article
- Developmental variations in recurrent spatiotemporal brain propagations from childhood to adulthood.Nature communications · 2026Article
- Fidelity of Spatiotemporal Patterns of Brain Activity Across Sampling Rate, Scan Duration, and Frequency Content.bioRxiv : the preprint server for biology · 2026Article
- Article
- A Method for Estimating Dynamic Functional Network Connectivity Gradients (dFNGs) From ICA Captures Smooth Inter-Network Modulation.Human brain mapping · 2025Article
- Neuromodulatory influences on propagation of traveling waves along the unimodal-transmodal gradient.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Coactivation patterns reveal the abnormality of dynamic state transitions between different psychiatric disorders.Scientific reports · 2025Article
- Understanding the Link Between Functional Profiles and Intelligence Through Dimensionality Reduction and Graph Analysis.Human brain mapping · 2025Article
- Infraslow Dynamic Patterns in Human Cortical Networks Track a Spectrum of External to Internal Attention.Human brain mapping · 2025Article
- Article
- QPPLab: A generally applicable software package for detecting, analyzing, and visualizing large-scale quasiperiodic spatiotemporal patterns (QPPs) of brain activity.bioRxiv : the preprint server for biology · 2025Article
- Altered functional connectivity and spatiotemporal dynamics in individuals with central disorders of hypersomnolence.Frontiers in neuroscience · 2025Article
- A function-based mapping of sensory integration along the cortical hierarchy.Communications biology · 2024Article
- Evolution of aberrant brain-wide spatiotemporal dynamics of resting-state networks in a Huntington's disease mouse model.Clinical and translational medicine · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The intrinsic activity of the human brain, observed with resting-state fMRI (rsfMRI) and functional connectivity, exhibits macroscale spatial organization such as functional networks and gradients. Dynamic analysis techniques have shown that functional connectivity is a mere summary of time-varying patterns with distinct spatial and temporal characteristics. A better understanding of these patterns might provide insight into aspects of the brain's intrinsic activity that cannot be inferred by functional connectivity or the spatial maps derived from it, such as functional networks and gradients. Here, we describe three spatiotemporal patterns of coordinated activity across the whole brain obtained by averaging similar ~20-second-long segments of rsfMRI timeseries. In each of these patterns, activity propagates along a particular macroscale functional gradient, simultaneously across the cerebral cortex and in most other brain regions. In some regions, like the thalamus, the propagation suggests previously-undescribed gradients. The coordinated activity across areas is consistent with known tract-based connections, and nuanced differences in the timing of peak activity between regions point to plausible driving mechanisms. The magnitude of correlation within and particularly between functional networks is remarkably diminished when these patterns are regressed from the rsfMRI timeseries, a quantitative demonstration of their significant role in functional connectivity. Taken together, our results suggest that a few recurring patterns of propagating intrinsic activity along macroscale gradients give rise to and coordinate functional connections across the whole brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.