SynthesisNeuroImage2021
Hearing loss impacts gray and white matter across the lifespan: Systematic review, meta-analysis and meta-regression.
Synthesis in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Brain Morphological Modifications in Congenital and Acquired Auditory Deprivation: A Systematic Review and Coordinate-Based Meta-Analysis.Frontiers in neuroscience · 2022Pooled it
- Differential cross-modal functional plasticity in deaf individuals: A meta-analysis of neuroimaging studies.iScience · 2026Article
- Hearing Loss, Cognitive Decline, and Dementia: Clinical Intersections.Audiology research · 2026Review
- A Life Without Olfactory Function Has Limited Effects on Cerebral White Matter Morphology.Neural plasticity · 2026Article
- Establishing New Pediatric Thresholds for Digits-In-Noise Testing.Laryngoscope investigative otolaryngology · 2025Article
- Regional gray matter thickness correlations of the hearing and deaf feline brains.Neuroimage. Reports · 2025Article
- Sensory Insights in Aging: Exploring the Impact on Improving Dietary Through Sensory Enhancement.Food science & nutrition · 2025Review
- Cross brain reshaping in congenital visual or hearing impairment: triple-network dysfunction.Brain communications · 2025Article
- Executive Function Associations With Audibility-Adjusted Speech Perception in Noise.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.Brain : a journal of neurology · 2024Article
- Cortical thickness differences between hearing and perinatally deaf cats using ultra-high field MRI.Neuroimage. Reports · 2024Article
- Early-stage use of hearing aids preserves auditory cortical structure in children with sensorineural hearing loss.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Motor Processing in Children With Cochlear Implants as Assessed by Functional Near-Infrared Spectroscopy.Perceptual and motor skills · 2024Article
- The value of synthetic MRI in detecting the brain changes and hearing impairment of children with sensorineural hearing loss.Frontiers in neuroscience · 2024Article
- The characteristics of brain structural remodeling in patients with unilateral vestibular schwannoma.Journal of neuro-oncology · 2023Article
- Hearing loss, depression, and cognition in younger and older adult CI candidates.Frontiers in neurology · 2023Article
- Subtle alterations of vestibulomotor functioning in conductive hearing loss.Frontiers in neuroscience · 2023Article
- Editorial: Quality of life in young cochlear implant recipients: Are there controlling factors and regional differences?Frontiers in psychology · 2022Article
- Volumetric analysis of the aging auditory pathway using high resolution magnetic resonance histology.Frontiers in aging neuroscience · 2022Article
- Effects of individualized brain anatomies and EEG electrode positions on inferred activity of the primary auditory cortex.Frontiers in neuroinformatics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Hearing loss is a heterogeneous disorder thought to affect brain reorganization across the lifespan. Here, structural alterations of the brain due to hearing loss are assessed by using unique effect size metrics based on Cohen's d and Hedges' g. These metrics are used to map coordinates of gray matter (GM) and white matter (WM) alterations from bilateral congenital and acquired hearing loss populations. A systematic review and meta-analysis revealed m = 72 studies with structural alterations measured with magnetic resonance imaging (MRI) (bilateral = 64, unilateral = 8). The bilateral studies categorized hearing loss into congenital and acquired cases (n = 7,445) and control cases (n = 2,924), containing 66,545 datapoint metrics. Hearing loss was found to affect GM and underlying WM in nearly every region of the brain. In congenital hearing loss, GM decreased most in the frontal lobe. Similarly, acquired hearing loss had a decrease in frontal lobe GM, albeit the insula was most decreased. In congenital, WM underlying the frontal lobe GM was most decreased. In congenital, the right hemisphere was more negatively impacted than the left hemisphere; however, in acquired, this was the opposite. The WM alterations most frequently underlined GM alterations in congenital hearing loss, while acquired hearing loss studies did not frequently assess the WM metric. Future studies should use the endophenotype of hearing loss as a prognostic template for discerning clinical outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.