ArticleJournal of neuroscience methods2021
Differences in cerebral blood vasculature and flow in awake and anesthetized mouse cortex revealed by quantitative optical coherence tomography angiography.
Article in Journal of neuroscience methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- No evidence of major integrative brain clearance impairment in an Alzheimer´s disease model of transgenic APPswe/PS1dE9 mice.Fluids and barriers of the CNS · 2026Article
- Continuous monitoring of blood-interstitial fluid intercompartmental molecular kinetics in freely moving animals.Science advances · 2026Article
- Cardiac pulse transfer along the cerebral microvascular network captured by laser speckle contrast imaging.Biomedical optics express · 2026Article
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- Rapid adaptive optics enabling near noninvasive high-resolution brain imaging in awake behaving mice.Nature communications · 2025Article
- Magnetic resonance imaging cerebral blood perfusion measurement in awake mice.Journal of neuroscience methods · 2025Article
- Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IPProceedings of the National Academy of Sciences of the United States of America · 2025Article
- High-fat feeding has sex-dependent effects on the structure and biomechanical properties of cerebral parenchymal arterioles and cognitive function.American journal of physiology. Heart and circulatory physiology · 2025Article
- 3D transcranial ultrasound localization microscopy in awake mice: protocol and open-source pipeline.Communications engineering · 2025Article
- Wearable optical coherence tomography angiography probe with extended depth of field.Journal of biomedical optics · 2025Article
- Isoflurane anesthesia alters 31P magnetic resonance spectroscopy markers compared to awake mouse brain.PloS one · 2025Article
- Optical coherence tomography (OCT) and OCT angiography: Technological development and applications in brain science.Theranostics · 2025Review
- Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer [Journal of neurochemistry · 2024Article
- Whole-brain responses to visual and auditory stimuli in anesthetized and minimally restrained awake mice using quiet zero echo time fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Wearable optical coherence tomography angiography probe for freely moving mice.Biomedical optics express · 2023Article
- Cortical spreading depolarization-induced constriction of penetrating arteries can cause watershed ischemia: A potential mechanism for white matter lesions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Isoflurane and ketamine-xylazine modify pharmacokinetics of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMost of the in vivo neurovascular imaging studies are performed in anesthetized animals. However, anesthesia significantly affects cerebral hemodynamics. NEW
methodWe applied optical coherence tomography (OCT) methods such as optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) to quantitatively evaluate the effect of anesthesia in cerebral vasculature and blood flow in mouse brain.
resultsThe OMAG results indicated the increase of large vessel diameter and capillary density induced by ketamine-xylazine and isoflurane, meaning that both anesthetics caused vasodilation. In addition, the preliminary results from DOMAG showed that isoflurane increased the baseline cerebral blood flow. COMPARISON WITH EXISTING
methodsIn comparison with other in vivo imaging modalities, OCT can provide label-free assessment of cortical tissue including tissue morphology, cerebral blood vessel network and flow information down to capillary level, with a large field of view and high imaging speed.
conclusionsOCT angiography methods demonstrated the ability to measure the differences in the baseline morphological and flow parameters of both large and capillary cerebrovascular networks between awake and anesthetized mice.
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