ReviewTrends in molecular medicine2021
Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Review in Trends in molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- BGP-15 Treatment Improves Follicle Growth and Alters Collagen Deposition in Mouse Transplanted Ovaries.Molecular reproduction and development · 2026Article
- Insulin-like growth factor 1 as a key paracrine mediator in mesenchymal stem cell-based intervention for ovarian ageing: a review.Journal of ovarian research · 2026Review
- Female fertility preservation: 25 years of progress, expanding indications and future prospects.Human reproduction update · 2026Review
- Cryopreservation of ovarian tissue - what's known so far and future perspectives.Frontiers in reproductive health · 2026Review
- "Forever fertile": ovarian tissue cryopreservation for an extended reproductive lifespan.Journal of assisted reproduction and genetics · 2025Review
- Beyond Earth, Beyond Time: Preserving Female Fertility in Space Missions.Journal of clinical medicine · 2025Review
- Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation.Frontiers in pharmacology · 2025Review
- Ovarian tissue cryopreservation and transplantation as a natural means to delay menopause.Archives of gynecology and obstetrics · 2024Review
- Maximizing Success: An Overview of Optimizing the Ovarian Tissue Transplantation Site.JBRA assisted reproduction · 2024Review
- Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation.American journal of obstetrics and gynecology · 2024Article
- Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency.Biomolecules · 2024Review
- High FSH levels impair VEGF secretion of human, frozen-thawed ovarian cortical tissue in vitro.Scientific reports · 2024Article
- Significance and Influence of Suturing for Ovarian Tissue Transplantation.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Comparison of orthotopic and heterotopic autologous ovarian tissue transplantation outcomes.Fertility and sterility · 2024Article
- Fertility preservation in pregnant cancer patients after first-trimester abortion: a new challenge with possible solutions.Journal of assisted reproduction and genetics · 2023Review
- Adverse effects of ovarian cryopreservation and auto-transplantation on ovarian grafts and quality of produced oocytes in a mouse model.Clinical science (London, England : 1979) · 2023Article
- Ovarian aging in humans: potential strategies for extending reproductive lifespan.GeroScience · 2023Review
- The Current Strategy in Hormonal and Non-Hormonal Therapies in Menopause-A Comprehensive Review.Life (Basel, Switzerland) · 2023Review
- The Aging Ovary and the Tales Learned Since Fetal Development.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2023Review
- Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?Human reproduction (Oxford, England) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
Ovarian tissue cryopreservation and autotransplantation can restore ovarian endocrine function and fertility and recently were changed from experimental to fertility preservation procedures for medical indications by the American Society of Reproductive Medicine. Such advances have resulted in discussions around the utility of ovarian cryopreservation in healthy women to preserve fertility and delay menopause or as a hormone replacement approach. Such 'elective' use of ovarian tissue cryopreservation requires a risk-benefit assessment. Here, we review evidence for and against the utility of ovarian tissue harvesting in healthy women, scrutinize recent and needed advances to enhance the feasibility of such an approach, and provide practice and future research guidelines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.