SynthesisDeutsches Arzteblatt international2020
Diagnosis, Treatment and Follow-up in Extracranial Carotid Stenosis.
Synthesis in Deutsches Arzteblatt international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Temporal trends in short- and long-term outcomes after carotid interventions for symptomatic or asymptomatic stenosis: a systematic review and meta-analysis.European stroke journal · 2026Pooled it
- Systematic review and meta-analysis of the diagnostic value of computed tomography angiography for severe internal carotid artery stenosis.BMC medical imaging · 2024Pooled it
- [Important recommendations of the German-Austrian S3 guidelines on management of extracranial carotid artery stenosis].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2022Guideline
- Trial
- Supra-aortic bypass reconstructions using ring-reinforced 8 mm polytetrafluoroethylene for debranching before thoracic endovascular aortic repair and for atherosclerotic lesions of the subclavian artery.Journal of vascular surgery cases and innovative techniques · 2026Article
- Carotid artery stenosis: a guide for clinicians.Future cardiology · 2026Review
- Radiation-Induced Carotid Artery Disease: Pathogenesis, Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2026Review
- Intraoperative completion study using three-dimensional computed tomography angiography in carotid endarterectomy surgery: Technical case series.Neurosurgical review · 2026Article
- Carotid atherosclerotic plaque vulnerability assessment from angiography-derived radial wall strain validated by MRI.Scientific reports · 2025Article
- Neurofibrillary tangles predict dementia in patients with carotid stenosis.Journal of vascular surgery · 2025Article
- Determinants of prehospital and in-hospital delay in patients with symptomatic carotid stenosis and their influence on the outcome after elective carotid endarterectomy.Stroke and vascular neurology · 2025Article
- 30-Day Outcomes of Real-World Elective Carotid Stenosis Treatment Using a Dual-Layer Micromesh Stent (ROADSAVER Study).Cardiovascular and interventional radiology · 2025Observational
- Spatial omics strategies for investigating human carotid atherosclerotic disease.Clinical and translational medicine · 2025Review
- [Stenting of the extracranial internal carotid artery].Innere Medizin (Heidelberg, Germany) · 2025Review
- Carotid artery stenosis and ischemic cerebrovascular events after radiotherapy in patients with head and neck cancer.PloS one · 2025Article
- Safety, efficacy and timing of antithrombotic therapy in emergency stenting of acute stroke patients with tandem lesions, German multicenter data-analysis.Frontiers in neurology · 2025Article
- Outcomes following carotid revascularization in patients with prior ipsilateral carotid artery stenting in the Vascular Quality Initiative.Journal of vascular surgery · 2024Article
- Association Between Hospital Policy on Local Versus General Anesthesia, and Outcomes of Carotid Endarterectomy: Secondary Data Analysis of the German Statutory Carotid Quality Assurance Database.Stroke (Hoboken, N.J.) · 2024Article
- Identification of patient characteristics that may improve procedure selection for the treatment of carotid stenosis.The British journal of surgery · 2024Article
- Association of Centre Quality Certification with Characteristics of Patients, Management, and Outcomes Following Carotid Endarterectomy or Carotid Artery Stenting.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAround 15% of cerebral ischemias are caused by lesions of the extracranial carotid artery. The goal of this guideline is to provide evidence- and consensus-based recommendations for the management of patients with extracranial carotid stenoses throughout Germany and Austria.
methodsA systematic literature search (1990-2019) and methodical assessment of existing guidelines and systematic reviews; consensus-based answers to 37 key questions with evidence-based recommendations.
resultsThe prevalence of extracranial carotid artery stenoses is around 4% overall, higher from the age of 65 years. The most important examination modality is duplex sonography. Randomized trials have shown that carotid endarterectomy (CEA) significantly reduces the 5-year risk of stroke in patients with 60-99 % asymptomatic stenoses (absolute risk reduction [ARR] 4.1% over 5 years, number needed to treat [NNT] 24) or 50-99% symptomatic stenoses (50-69%: ARR 4.6 % over 5 years, NNT 22; 70-99%: 15.9 % over 5 years, NNT 6). With the aid of intensive conservative treatment, the carotid artery-associated risk of stroke can be reduced to as little as 1% per year. Critical determination of indications and strict quality criteria are therefore necessary for CEA and carotid artery stenting (CAS). Systematic reviews of controlled trials comparing CEA and CAS show that the procedural risk of stroke is higher for CAS (asymptomatic: 2.6% versus 1.3%; symptomatic: 6.2% versus 3.8%). There are no differences in the long term. CEA is recommended as standard procedure for high-grade asymptomatic and moderate to high-grade symptomatic carotid artery stenoses; CAS may be considered as an alternative. For both procedures, the periprocedural combined rate of stroke or death should not exceed 2% for asymptomatic stenoses or 4% for symptomatic stenoses.
conclusionFuture studies should evaluate even better selection criteria for optimal individualized treatment, whether conservative, surgical, or endovascular.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.