Evidence map›Paper›PMID 33549117›Full record

ArticleJournal of medical case reports2021

A bedridden young lady with hypophosphatemic rickets treated with denosumab: a case report.

Butheinah A Al-Sharafi, Nuha A Al-Yousfi, Said A Bamashmus

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Butheinah A Al-SharafiDepartment of Medicine, School of Medicine and Health Sciences, Sana'a University, PO Box 12268, Sana'a, Yemen. balsharafi@hotmail.com.
Nuha A Al-YousfiDepartment of Medicine, School of Medicine and Health Sciences, Sana'a University, PO Box 12268, Sana'a, Yemen.
Said A BamashmusDepartment of Orthopedic Surgery, University of Science and Technology Hospital, PO Box 13061, Sana'a, Yemen.
Sana'a University · YEUniversity of Science and Technology · YE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypophosphatemic rickets is associated with delayed walking, bone deformities, growth failure and physical dysfunction that can limit daily activities. Treatment consists of phosphate salts and calcitriol. We report a case that received denosumab with marked improvement in her condition. CASE PRESENTATION: A 24-year-old Yemeni female with hypophosphatemic rickets presented to an endocrinologist with severe weakness and severe pain in the extremities, she had been bedridden for the last 4 years. Bone density showed severe osteoporosis (T score of hip was - 5.0 and Z score of hip was - 5.0, T score of the spine was - 6.0 and Z score of the spine was - 6.1) so the patient was started on denosumab in addition to calcitriol and after 7months she was feeling stronger and felt she could stand assisted and was walking with assistance within 9 months and after 1.5 years of treatment she was walking unassisted.

conclusionDenosumab is an effective treatment for osteoporosis, we used it in our patient in addition to calcitriol because she had severe osteoporosis due to long standing hypophosphatemic rickets that had not been treated properly, the patient improved markedly and regained the ability to walk again after being bedridden for 4 years. It may be a drug to consider in such cases although further studies need to be done to confirm this.

Indexed as

OsteomalaciaRickets, HypophosphatemicAdultBone DensityCalcitriolDenosumabFemaleHumansYoung AdultCalcitriolDenosumabCase reportDenosumabHyperparathyroidismHypophosphatemic ricketsOsteomalaciaOsteoporosis

Identifiers

PMID33549117
PMCPMC7868015
OpenAlexW3127025875

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.