Evidence map›Paper›PMID 33548225›Full record

ArticleThe Journal of biological chemistry

Binding of calcium and magnesium to human cardiac troponin C.

Kaveh Rayani, Justin Seffernick, Alison Yueh Li, Jonathan P Davis, Anne Marie Spuches, Filip Van Petegem, R John Solaro, Steffen Lindert, Glen F Tibbits

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. The effect of MgThe FEBS journal · 2022
    Article
  12. Article
  13. Article
  14. Cardiomyocyte Dysfunction in Inherited Cardiomyopathies.International journal of molecular sciences · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Kaveh RayaniMolecular Cardiac Physiology Group, Simon Fraser University, Burnaby, British Columbia, Canada.
Justin SeffernickDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.
Alison Yueh LiMolecular Cardiac Physiology Group, Simon Fraser University, Burnaby, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.
Jonathan P DavisDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio, USA.
Anne Marie SpuchesDepartment of Chemistry, East Carolina University, 300 Science and Technology Building, Greenville, North Carolina, USA.
Filip Van PetegemDepartment of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.
R John SolaroDepartment of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Steffen LindertDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.
Glen F TibbitsMolecular Cardiac Physiology Group, Simon Fraser University, Burnaby, British Columbia, Canada; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada; Cardiac Group, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Electronic address: tibbits@sfu.ca.
The Ohio State University · USSimon Fraser University · CAUniversity of British Columbia · CAEast Carolina University · USUniversity of Illinois Chicago · US

Funding

Molecular models to characterize actions of calcium sensitizing drugsR01HL137015 · NHLBI · OHIO STATE UNIVERSITY · PI LINDERT, STEFFEN · 2018 to 2022
$1.8M
NHLBI NIH HHS R01 HL137015
6 · The paper itself

Abstract

Cardiac muscle thin filaments are composed of actin, tropomyosin, and troponin that change conformation in response to Ca

Indexed as

Binding SitesCalciumCations, DivalentHumansMagnesiumMyocardiumProtein BindingThermodynamicsTroponin CCalciumCations, DivalentMagnesiumTroponin CcalorimetrycontractilityITCMD simulationmolecular dynamicsmyofilamentthermodynamic integration

Identifiers

PMID33548225
PMCPMC7961095
OpenAlexW3126168703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.