ArticleNeuron2021
Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons.
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Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 55 citations in OpenAlex.
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- Microglial galectin-3 disrupts parvalbumin interneurons and hippocampal synchrony, driving cognitive deficits.Journal of neuroinflammation · 2026Article
- Achieving cell-type specific transduction with adeno-associated viral vectors in pigeons.Current research in neurobiology · 2026Article
- GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.Translational psychiatry · 2026Article
- Extracellular space diffusion modelling identifies distinct functional advantages of glutamatergic and GABAergic synapse geometries.Fluids and barriers of the CNS · 2026Article
- Neuronal Sik1 in the Hypothalamic Paraventricular Nucleus Decreases Blood pressure Elevation Following a High-Salt Diet.Molecular neurobiology · 2026Article
- Theta-shaking mitigates cognitive-emotional decline via subiculum and ventral septum metabolic plasticity.Mechanobiology in medicine · 2025Article
- Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries.bioRxiv : the preprint server for biology · 2025Article
- Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity.PLoS computational biology · 2025Article
- Cathodal weak direct current decreases epileptic excitability with reduced neuronal activity and enhanced delta oscillations.The Journal of physiology · 2025Article
- Role and mechanisms of interneurons in chronic pain and pain-induced cognitive impairment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Deciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse.Neuroscience bulletin · 2025Article
- GABAergic Progenitor Cell Graft Rescues Cognitive Deficits in Fragile X Syndrome Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- AKT/mTOR/BDNF pathway mediates the antidepressant-like effects of NAc-DBS in a mouse model of depression.Frontiers in behavioral neuroscience · 2025Article
- Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.Science (New York, N.Y.) · 2024Article
- Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.Nature communications · 2024Article
- Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Gamma oscillation plasticity is mediated via parvalbumin interneurons.Science advances · 2024Article
- Role of CAMK2D in neurodevelopment and associated conditions.American journal of human genetics · 2024Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Xingzhi HeDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Jiarui LiDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Guangjun ZhouDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Jing YangDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Sam McKenzieDepartment of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA.
Yanjun LiDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Wenwen LiDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Jun YuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Yang WangDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Jing QuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Zhiying WuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China.
Hailan HuDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China; Research Units for Emotion and Emotion Disorders, Chinese Academy of Medical Sciences, Beijing 100730, China.
Shumin DuanDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China; Research Units for Emotion and Emotion Disorders, Chinese Academy of Medical Sciences, Beijing 100730, China.
Huan MaDepartment of Neurobiology and Department of Neurology of Second Affiliated Hospital, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310058, China; Research Units for Emotion and Emotion Disorders, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address: mah@zju.edu.cn.
Nanjing Brain Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of New Mexico · US
Funding
Investigation into the synaptic origins of hippocampal replayR00MH118423 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MCKENZIE, SAMUEL ARNOLD · 2020 to 2022
$923kInvestigation into the synaptic origins of hippocampal replayK99MH118423 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCKENZIE, SAMUEL ARNOLD · 2018 to 2019
$264kNIMH NIH HHS K99 MH118423NIMH NIH HHS R00 MH118423
Abstract
Mental experiences can become long-term memories if the hippocampal activity patterns that encode them are broadcast during network oscillations. The activity of inhibitory neurons is essential for generating these neural oscillations, but molecular control of this dynamic process during learning remains unknown. Here, we show that hippocampal oscillatory strength positively correlates with excitatory monosynaptic drive onto inhibitory neurons (E→I) in freely behaving mice. To establish a causal relationship between them, we identified γCaMKII as the long-sought mediator of long-term potentiation for E→I synapses (LTP
Indexed as
AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2HippocampusInterneuronsLearningMiceMice, Inbred C57BLNeuronal PlasticityCalcium-Calmodulin-Dependent Protein Kinase Type 2CaMKIIinhibitory interneuronslearning and memoryLTPnetwork oscillationsnetwork plasticitysynaptic plasticity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.