Evidence map›Paper›PMID 33548044›Full record

ArticleInternational urology and nephrology2021

COVID-19 in chronic kidney disease: a retrospective, propensity score-matched cohort study.

Ahmet Burak Dirim, Erol Demir, Serap Yadigar, Nurana Garayeva, Ergun Parmaksiz, Seda Safak, Kubra Aydin Bahat, Ali Riza Ucar, Meric Oruc, Ozgur Akin Oto and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Ahmet Burak DirimDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. ahmetburakdirim@gmail.com.ORCID http://orcid.org/0000-0003-2262-8627
Erol DemirDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Serap YadigarDivision of Nephrology, Department of Internal Medicine, Dr. Lutfi Kirdar Kartal Teaching and Research Hospital, Istanbul, Turkey.
Nurana GarayevaDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Ergun ParmaksizDivision of Nephrology, Department of Internal Medicine, Dr. Lutfi Kirdar Kartal Teaching and Research Hospital, Istanbul, Turkey.
Seda SafakDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Kubra Aydin BahatDivision of Nephrology, Department of Internal Medicine, Dr. Lutfi Kirdar Kartal Teaching and Research Hospital, Istanbul, Turkey.
Ali Riza UcarDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Meric OrucDivision of Nephrology, Department of Internal Medicine, Dr. Lutfi Kirdar Kartal Teaching and Research Hospital, Istanbul, Turkey.
Ozgur Akin OtoDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Alpay MedetalibeyogluDepartment of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Seniha BasaranDepartment of Infectious Diseases and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Gunseli OrhunDepartment of Anesthesiology and Intensive Care, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Halil YaziciDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Aydin TurkmenDivision of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Istanbul University · TRDr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi · TRIstanbul Bilim University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prognostic factors for COVID-19 in patients with chronic kidney disease (CKD) are uncertain. We conducted a study to compare clinical and prognostic features between hospitalized COVID-19 patients with and without CKD.

methodsFifty-six patients with stage 3-5 CKD and propensity score-matched fifty-six patients without CKD were included in the study. Patients were followed-up at least fifteen days or until death after COVID-19 diagnosis. The endpoints were death from all causes, development of acute kidney injury (AKI) or cytokine release syndrome or respiratory failure, or admission to the intensive care unit (ICU).

resultsAll patients were reviewed retrospectively over a median follow-up of 44 days (IQR, 36-52) after diagnosis of COVID-19. Patients with CKD had higher intensive care unit admission and mortality rates than the patients without CKD, but these results did not reach statistical significance (16 vs. 19; p = 0.54 and 11 vs. 16, p = 0.269, respectively). The frequency of AKI development was significantly higher in predialysis patients with CKD compared to the other group (8 vs. 5; p < 0.001), but there was no significant difference between the groups in terms of cytokine release syndrome (13 vs. 8; p = 0.226), follow-up in the ICU (19 vs. 16; p = 0.541), and respiratory failure (25 vs. 22, p = 0.566). Multivariate logistic regression analysis revealed that respiratory failure and AKI were independent risk factors for mortality.

conclusionThe mortality rates of COVID-19 patients with CKD had higher than COVID-19 patients without CKD. Also, AKI and respiratory failure were independently related to mortality.

Indexed as

Acute Kidney InjuryAdultAgedCOVID-19Critical CareCytokine Release SyndromeFemaleHospitalizationHospital MortalityHumansMaleMiddle AgedPropensity ScoreRenal Insufficiency, ChronicRespiratory InsufficiencyRetrospective StudiesAcute kidney injuryChronic kidney diseaseCOVID-19End-stage kidney disease

Identifiers

PMID33548044
PMCPMC7864795
OpenAlexW3128713323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.