ArticleEnvironmental science and pollution research international2021
Vitamin C rescues inflammation, immunosuppression, and histopathological alterations induced by chlorpyrifos in Nile tilapia.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- The protective role of Artemisia annua against chlorpyrifos toxicity in Nile tilapia.Scientific reports · 2026Article
- Effect of plant and microalgae on immune-related genes and resistance of nile tilapia (Oreochromis niloticus) against Aeromonas hydrophila.Scientific reports · 2025Article
- Article
- The beneficial impact of oregano essential oil supplementation on growth, physiological function, antioxidant activity, and immune response in Nile tilapia (Open veterinary journal · 2025Article
- A Blend of natural phytobiotics enhances growth performance, feed efficiency, and the immuno-health status of fingerlings of Nile tilapia (Open veterinary journal · 2025Review
- Temperature and feeding frequency: interactions with growth, immune response, and water quality in juvenile Nile tilapia.BMC veterinary research · 2024Article
- Interactive effects of water temperature and dietary protein on Nile tilapia: growth, immunity, and physiological health.BMC veterinary research · 2024Article
- Assessing organophosphate insecticide retention in muscle tissues of juvenile common carp fish under acute toxicity tests.Toxicology reports · 2024Article
- Exploring the impacts of different fasting and refeeding regimes on Nile tilapia (Oreochromis niloticus L.): growth performance, histopathological study, and expression levels of some muscle growth-related genes.Fish physiology and biochemistry · 2022Article
- Toxic effects of chlorpyrifos on the growth, hematology, and different organs histopathology of Nile tilapia,Saudi journal of biological sciences · 2022Article
- Immunosuppression and apoptosis activation mediated by p53-Bcl2/Bax signaling pathway -The potential mechanism of goldfish (Frontiers in immunology · 2022Article
- Isatis phytogenic relieved atrazine induced growth retardation, hepato-renal dysfunction, and oxidative stress in Nile tilapia.Saudi journal of biological sciences · 2022Article
- Ascorbic Acid Regulates the Immunity, Anti-Oxidation and Apoptosis in AbaloneAntioxidants (Basel, Switzerland) · 2021Article
- Molecular Detection, Serotyping, and Antibiotic Resistance of Shiga ToxigenicAntibiotics (Basel, Switzerland) · 2021Article
- The influence of coconut oil on the growth, immune, and antioxidative responses and the intestinal digestive enzymes and histomorphometry features of Nile tilapia (Oreochromis niloticus).Fish physiology and biochemistry · 2021Article
- Role of Fucoidan on the Growth Behavior and Blood Metabolites and Toxic Effects of Atrazine in Nile TilapiaAnimals : an open access journal from MDPI · 2021Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorpyrifos (CPF) is an extensive environmental contaminant and disrupts the physiological status of living organisms. CPF is found to hinder the health of aquatic organisms and ecological function in aquatic systems. The current study aimed at evaluating the protective effects of vitamin C (VC) on the immune response, hematological parameters, and histopathological alterations in Nile tilapia exposed to CPF. Nile tilapia were exposed to waterborne CPF (15 μg/L) for 30 days. Fish were divided into control group: received basal diet; CPF group: received basal diet and exposed to waterborne CPF; VC group: received basal diet plus 0.8 mg VC/kg; and CPF/VC group: received basal diet plus 0.8 mg VC/kg and exposed to waterborne CPF. Blood samples were taken after 15 days and 30 days of the treatment. Liver, gills, and intestine tissues were collected on the 30th day of treatment. CPF showed a deleterious effect on fish's growth performance; it decreased the weight gain by 6%, while VC increased it by 17-23% compared to the control group. CPF group recorded the lowest survival rate (83%), while VC achieved survivability of 96.7% and 93.3% in VC and CPF/VC groups, respectively. The blood picture revealed moderate changes in the CPF group, where the marked alteration was in the hemoglobin concentration and white blood cells. CPF disrupted the hepatic and renal function. Serum lysozyme activity, phagocytic activity, and phagocytic index displayed a dramatic decline in the CPF group but enhanced in VC and CPF/VC groups. An upregulation was observed in antioxidant genes (catalase and glutathione peroxidase), heat shock protein 70, caspase-3, and the cytokines interleukin 1β, interleukin 8, and interferon-gamma in the CPF group. Simultaneously, moderate or normal levels were shown in the VC and CPF/VC groups. CPF altered the histoarchitecture of gills, intestine, and hepatopancreas with apparent degenerative changes possibly resulted from the oxidative stress. At the same time, VC retained the normal structure of the studied tissues. This study raises concerns about the safety of CPF and its impact on the aquatic environment. VC has a high potential to restore the normal physiology of fish exposed to CPF.
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