ArticleNeuroscience bulletin2021
Projections from D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Play Distinct Roles in Reward and Aversion.
Article in Neuroscience bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Mesolimbic Dopaminergic Encoding of Decision Value: Linking Phenotype-Specific Signals to Strategic Adaptation.Neuroscience bulletin · 2026Article
- D1 and D2 neurons in medial nucleus accumbens participate in chronic orofacial pain phenotypes.Pain reports · 2026Article
- Nucleus accumbens DRD2 receptor agonism attenuates escape behavior.Frontiers in neuroscience · 2026Article
- Sex Differences in the Ventral Subiculum's Microcircuitry and Function.Hippocampus · 2026Review
- PVN-NAc Shell-VP Circuit OT and OTR Neurons Regulate Pair Bonding via D2R and D1R.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Nucleus accumbens D2-expressing neurons: Balancing reward and licking disruption through rhythmic optogenetic stimulation.PloS one · 2025Article
- Neural Circuitry Involving Substance P in Male Sexual Behavior.Neuroscience bulletin · 2024Article
- Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 or positive allosteric modulation of the protein affects the motivation to chronically self-administer nicotine.Scientific reports · 2024Article
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
- Neuropeptides Modulate Feeding via the Dopamine Reward Pathway.Neurochemical research · 2023Review
- Hyperactivity of the Lateral Septum Leads to Hypersensitivity in Susceptible Mice.Neuroscience bulletin · 2023Article
- Article
- Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice.Neuroscience bulletin · 2023Article
- Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- The antipsychotic drug sulpiride in the ventral pallidum paradoxically impairs learning and induces place preference.Scientific reports · 2022Article
- Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice.Nature communications · 2022Article
- Targeting 5-HT as a Potential Treatment for Social Deficits in Autism.Neuroscience bulletin · 2022Article
- Plasticity in astrocyte subpopulations regulates heroin relapse.Science advances · 2022Article
- A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state.Cell research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleus accumbens shell (NAcSh) plays an important role in reward and aversion. Traditionally, NAc dopamine receptor 2-expressing (D2) neurons are assumed to function in aversion. However, this has been challenged by recent reports which attribute positive motivational roles to D2 neurons. Using optogenetics and multiple behavioral tasks, we found that activation of D2 neurons in the dorsomedial NAcSh drives preference and increases the motivation for rewards, whereas activation of ventral NAcSh D2 neurons induces aversion. Stimulation of D2 neurons in the ventromedial NAcSh increases movement speed and stimulation of D2 neurons in the ventrolateral NAcSh decreases movement speed. Combining retrograde tracing and in situ hybridization, we demonstrated that glutamatergic and GABAergic neurons in the ventral pallidum receive inputs differentially from the dorsomedial and ventral NAcSh. All together, these findings shed light on the controversy regarding the function of NAcSh D2 neurons, and provide new insights into understanding the heterogeneity of the NAcSh.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.