Evidence map›Paper›PMID 33548018›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2021

Prognostic impact of incidentally detected hepatocellular carcinoma in explanted livers after living donor liver transplantation.

Muthukumarassamy Rajakannu, Mukul Vij, Taheer Mobin Ahmed Shaikh, Ashwin Rammohan, Mettu Srinivas Reddy, Mohamed Rela

Abstract readEvaluation Study
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In one paragraph

Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Editorial commentary on the Indian Journal of Gastroenterology January-February 2021.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Muthukumarassamy RajakannuDr. Rela Institute and Medical Centre, 7, CLC Works Road, Chromepet, Chennai, 600 044, India.ORCID 0000-0001-6600-7553
Mukul VijDr. Rela Institute and Medical Centre, 7, CLC Works Road, Chromepet, Chennai, 600 044, India.
Taheer Mobin Ahmed ShaikhDr. Rela Institute and Medical Centre, 7, CLC Works Road, Chromepet, Chennai, 600 044, India.
Ashwin RammohanDr. Rela Institute and Medical Centre, 7, CLC Works Road, Chromepet, Chennai, 600 044, India.
Mettu Srinivas ReddyDr. Rela Institute and Medical Centre, 7, CLC Works Road, Chromepet, Chennai, 600 044, India.
Mohamed RelaDr. Rela Institute and Medical Centre, 7, CLC Works Road, Chromepet, Chennai, 600 044, India. mohamed.rela@gmail.com.
Bharath University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of incidentally detected hepatocellular carcinoma (iHCC) in explanted liver on the prognosis of the patients undergoing orthotopic liver transplantation remains controversial with several studies reporting survival worse than true non-hepatocellular carcinoma (non-HCC) recipients. Patients undergoing living donor liver transplantation (LDLT) have the benefit of a shorter waiting time to transplant which in principle should reduce the frequency of new tumors developing while waiting for transplant. We aimed to evaluate the incidence, histopathological features, and impact of iHCC on short- and long-term outcomes in adult LDLT recipients.

methodsThe present study retrospectively analyzed the patients' demographics, tumor characteristics, and outcomes of iHCC in adult patients undergoing LDLT for non-HCC indications at our center between August 2009 and March 2018.

resultsFive hundred and forty-five adults underwent LDLT in our center during the study period. iHCC was detected in the explanted livers in 28 patients (5.1%) out of 545 LDLTs. Only one patient had iHCC beyond Milan criteria. No tumor recurrence was observed in the iHCC cohort after a median follow-up of 28 months. Five-year overall and recurrence-free survival was 96.4%.

conclusionsIncidence of iHCC in explanted livers after LDLT is low and most patients have very early-stage tumors with excellent recurrence-free survival. Hence, no specific post-transplant surveillance or treatment is necessary.

Indexed as

Carcinoma, HepatocellularFemaleHumansIncidental FindingsLiverLiver NeoplasmsLiver TransplantationLiving DonorsMaleMiddle AgedNeoplasm Recurrence, LocalPostoperative ComplicationsPrognosisProspective StudiesRetrospective StudiesRisk FactorsChronic liver diseaseCirrhosisHepatocellular carcinomaLiver cancerLiver transplantationMalignancyNon-alcoholic steatohepatitisPrognosisRecurrenceSurvivalViral hepatitis

Identifiers

PMID33548018
OpenAlexW3128547783

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.