Evidence map›Paper›PMID 33548016›Full record

ArticleClinical and experimental nephrology2021

Association of serum lncRNA H19 expression with inflammatory and oxidative stress markers and routine biochemical parameters in chronic kidney disease.

Hamza Malik Okuyan, Serdar Dogan, Menderes Yusuf Terzi, Mehmet A Begen, Faruk Hilmi Turgut

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Article in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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  11. The relationship between long noncoding RNAInternational journal of medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hamza Malik OkuyanDepartment of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Sakarya University of Applied Sciences, Sakarya, Turkey. hokuyan@uwo.ca.
Serdar DoganDepartment of Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.
Menderes Yusuf TerziDepartment of Medical Biology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.
Mehmet A BegenDepartment of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Ivey Business School, University of Western Ontario, London, Ontario, Canada.
Faruk Hilmi TurgutDepartment of Nephrology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.
Mustafa Kemal University · TRSakarya University · TRWestern University · CA

Funding

Mustafa Kemal Üniversitesi 19.M.013
6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is a disorder that affects millions worldwide, and current treatment options aiming at inhibiting the progression of kidney damage are limited. Long noncoding RNA (lncRNA) H19 is one of the first explored lncRNAs and its deregulation is associated with renal pathologies, such as renal cell injury and nephrotic syndrome. However, there is still no research investigating the connection between serum lncRNA H19 expressions and clinical outcomes in CKD patients. Therefore, we investigated the relation of serum lncRNA H19 expressions with routine biochemical parameters, inflammatory cytokines, oxidative stress and mineralization markers in advanced CKD patients.

methodslncRNA H19 serum levels from 56 CKD patients and 20 healthy controls were analyzed with reverse-transcription quantitative polymerase chain reaction method. Serum tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and osteocalcin (OC) levels were measured with enzyme linked-immunosorbent assay. Total antioxidant status (TAS) and total oxidative status (TOS) levels were evaluated by the routine measurement method.

resultsWe found that lncRNA H19 expressions were upregulated in patients with CKD compared to the controls. Furthermore, lncRNA H19 relative expression levels showed a negative relationship with glomerular filtration rate (GFR) while it was positively correlated with ferritin, phosphorus, parathyroid hormone, TNF-α, IL-6, OC, TAS and TOS levels.

conclusionlncRNA H19 expressions were increased in CKD stage 3-5 and HD patients, and elevated lncRNA H19 expressions were associated with decreased glomerular filtration rate, inflammation, and mineralization markers in these patients.

Indexed as

AdultAgedBiomarkersCase-Control StudiesC-Reactive ProteinFemaleFerritinsGlomerular Filtration RateHumansInflammationInterleukin-6MaleMiddle AgedOsteocalcinOxidative StressParathyroid HormoneBGLAP protein, humanBiomarkersC-Reactive ProteinFerritinsH19 long non-coding RNAIL6 protein, humanInterleukin-6OsteocalcinParathyroid HormonePhosphorusRNA, Long NoncodingRNA, MessengerTumor Necrosis Factor-alphaChronic kidney diseaseIL-6lncRNA H19Oxidative stressTNF-α

Identifiers

PMID33548016
OpenAlexW3128580462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.