Evidence map›Paper›PMID 33547995›Full record

ArticleMetabolic brain disease2021

Alpha-lipoic acid ameliorates tauopathy-induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor.

Elahe Zarini-Gakiye, Nima Sanadgol, Kazem Parivar, Gholamhassan Vaezi

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elahe Zarini-GakiyeDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Nima SanadgolDepartment of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran. n.sanadgol@uoz.ac.ir.ORCID 0000-0002-4509-5336
Kazem ParivarDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Gholamhassan VaeziDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. gh.vaezi@yahoo.com.
Islamic Azad University, Science and Research Branch · IRZabol University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tauopathies belong to a heterogeneous class of neuronal diseases resulting in the metabolic disturbance. A disulfide natural compound of Alpha-Lipoic acid (ALA) has shown numerous pharmacologic, antioxidant, and neuroprotective activities under neuropathological conditions. The aim of this study was to investigate the neuroprotective effects of ALA on the tauopathy-induced oxidative disturbance and behavioral deficits. The transgenic Drosophila model of tauopathy induced by human tau

Indexed as

Age FactorsAnimalsAnimals, Genetically ModifiedAntioxidantsApoptosisCaspasesDrosophilaDrosophila ProteinsFemaleHomeostasisInhibitor of Apoptosis ProteinsLocomotionMaleOxidation-ReductionOxidative StressReactive Oxygen SpeciesAntioxidantsCaspasesDIAP1 protein, DrosophiladrICE protein, DrosophilaDrosophila ProteinsInhibitor of Apoptosis ProteinsReactive Oxygen SpeciesThioctic AcidAgingApoptosis pathwayMetabolic disturbanceOxidative stressTauopathy

Identifiers

PMID33547995
OpenAlexW3127901193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.