Evidence map›Paper›PMID 33547985›Full record

ArticleInternational journal of computer assisted radiology and surgery2021

Differential diagnosis of ameloblastoma and odontogenic keratocyst by machine learning of panoramic radiographs.

Zijia Liu, Jiannan Liu, Zijie Zhou, Qiaoyu Zhang, Hao Wu, Guangtao Zhai, Jing Han

Open access · hybridAbstract read
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Performance of AI Chatbots in Preliminary Diagnosis of Maxillofacial Pathologies.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zijia Liu *School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jiannan Liu *Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zijie ZhouShanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiaoyu ZhangShanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hao WuCollege of Stomatology, Weifang Medical University, Weifang, China.
Guangtao Zhai *School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. zhaiguangtao@sjtu.edu.cn.
Jing Han *Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hanjing0808@163.com.
Shanghai Jiao Tong University · CNShanghai Ninth People's Hospital · CNWeifang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe differentiation of the ameloblastoma and odontogenic keratocyst directly affects the formulation of surgical plans, while the results of differential diagnosis by imaging alone are not satisfactory. This paper aimed to propose an algorithm based on convolutional neural networks (CNN) structure to significantly improve the classification accuracy of these two tumors.

methodsA total of 420 digital panoramic radiographs provided by 401 patients were acquired from the Shanghai Ninth People's Hospital. Each of them was cropped to a patch as a region of interest by radiologists. Furthermore, inverse logarithm transformation and histogram equalization were employed to increase the contrast of the region of interest (ROI). To alleviate overfitting, random rotation and flip transform as data augmentation algorithms were adopted to the training dataset. We provided a CNN structure based on a transfer learning algorithm, which consists of two branches in parallel. The output of the network is a two-dimensional vector representing the predicted scores of ameloblastoma and odontogenic keratocyst, respectively.

resultsThe proposed network achieved an accuracy of 90.36% (AUC = 0.946), while sensitivity and specificity were 92.88% and 87.80%, respectively. Two other networks named VGG-19 and ResNet-50 and a network trained from scratch were also used in the experiment, which achieved accuracy of 80.72%, 78.31%, and 69.88%, respectively.

conclusionsWe proposed an algorithm that significantly improves the differential diagnosis accuracy of ameloblastoma and odontogenic keratocyst and has the utility to provide a reliable recommendation to the oral maxillofacial specialists before surgery.

Indexed as

Diagnosis, DifferentialMachine LearningNeural Networks, ComputerAlgorithmsAmeloblastomaChinaHumansOdontogenic CystsRadiographyRadiography, PanoramicRadiologistsReproducibility of ResultsRotationSensitivity and SpecificityAmeloblastomaDeep learningMachine learningOdontogenic keratocyst

Identifiers

PMID33547985
PMCPMC7946691
OpenAlexW3128672304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.