Evidence map›Paper›PMID 33547882›Full record

ArticleNeuropsychopharmacology reports2021

Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT

Yoko Hagino, Frank Scott Hall, George R Uhl, Ichiro Sora, Kazutaka Ikeda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Yoko HaginoAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Frank Scott HallDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, USA.
George R UhlNeurology and Research Services, New Mexico VA Healthcare System, Albuquerque, NM, USA.
Ichiro SoraDepartment of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0003-0741-8373
Kazutaka IkedaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID 0000-0001-8342-0278
Tokyo Metropolitan Institute of Medical Science · JPKobe University · JPNew Mexico VA Health Care System · USUniversity of Toledo · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims5-Methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a synthetic orally active hallucinogenic tryptamine analogue. The present study examined whether the effects of 5-MeO-DIPT involve the serotonin transporter (SERT) and serotonin 5-hydroxytryptamine-1A (5-HT

methodsWe investigated the effects of 5-MeO-DIPT on extracellular 5-HT (5-HT

results5-MeO-DIPT decreased 5-HT

conclusion5-MeO-DIPT influences both 5-HT

Indexed as

5-Methoxytryptamine8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsCorpus StriatumFemaleMaleMiceMice, KnockoutMicrodialysisPiperazinesPrefrontal CortexPyridinesReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Plasma Membrane Transport Proteins5-methoxy-N,N-diisopropyltryptamine5-Methoxytryptamine8-Hydroxy-2-(di-n-propylamino)tetralinHtr1a protein, mouseN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidePiperazinesPyridinesReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouse5-HT1A serotonin receptor5-MeO-DIPTprefrontal cortexserotonin transporterstriatum

Identifiers

PMID33547882
PMCPMC8182963
OpenAlexW3126258570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.