Evidence map›Paper›PMID 33547881›Full record

ArticleNeuropsychopharmacology reports2021

Effects of RORγt overexpression on the murine central nervous system.

Tetsuya Sasaki, Rei Nagata, Satoru Takahashi, Yosuke Takei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tetsuya SasakiFaculty of Medicine, Department of Anatomy and Neuroscience, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID 0000-0002-7723-4417
Rei NagataFaculty of Medicine, Department of Anatomy and Neuroscience, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Satoru TakahashiFaculty of Medicine, Department of Anatomy and Embryology, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID 0000-0002-8540-7760
Yosuke TakeiFaculty of Medicine, Department of Anatomy and Neuroscience, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID 0000-0002-5026-8027
University of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveT helper 17 (Th17) cells are a subset of CD4

resultsRORγt Tg mice exhibited elevated Rorc and IL-17A mRNA expression in the colon, as well as a chronic increase in circulating IL-17A. We found that the immunoreactivity of Iba1 and density of microglia were lower in the dentate gyrus of RORγt Tg mice compared with wild-type mice. However, GFAP

conclusionOur findings indicate that a continuous increase of IL-17A in response to RORγt overexpression resulted in decreased microglia activity in the dentate gyrus, but had only a subtle effect on murine hippocampal functions.

Indexed as

AnimalsAstrocytesBehavior, AnimalColonDentate GyrusHippocampusInterleukin-17MaleMiceMice, Inbred C57BLMice, TransgenicMicrogliaNuclear Receptor Subfamily 1, Group F, Member 3Recognition, PsychologyRNA, MessengerSpatial LearningIl17a protein, mouseInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3RNA, MessengerRorc protein, mouseAstrocyteHippocampusIL-17AMicrogliaRORγt

Identifiers

PMID33547881
PMCPMC8182958
OpenAlexW3115254120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.