Evidence map›Paper›PMID 33547696›Full record

ArticleJournal of veterinary internal medicine2021

Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study.

Crystal Lindaberry, Shelly Vaden, Kathleen M Aicher, Gabriela Seiler, James Robertson, Rachel Cianciolo, Ching Yang, Jody L Gookin

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Crystal LindaberryDepartment of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Shelly VadenDepartment of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0003-4402-7830
Kathleen M AicherDepartment of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
Gabriela SeilerDepartment of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0003-0643-8436
James RobertsonCollege of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Rachel CiancioloDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Ching YangDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Jody L GookinDepartment of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0002-2911-0874
North Carolina State University · USThe Ohio State University · US

Funding

American Kennel Club Canine Health Foundation 01986American Shetland Sheepdog AssociationCollie Health Foundation
6 · The paper itself

Abstract

backgroundProteinuria is an independent risk factor for morbidity and mortality in dogs. An association between proteinuria and gallbladder mucocele formation in dogs is unknown.

objectiveDetermine if gallbladder mucocele formation or clinicopathologic comorbidities are associated with proteinuria. ANIMALS: Twenty-five dogs with mucocele formation and 25 breed and age-matched control dogs from a prior study.

methodsRetrospective case control study. Proteinuria defined by calculated urine dipstick protein concentration (mg/mL) to urine specific gravity (USG) ratio. Clinicopathologic findings, postcosyntropin cortisol concentration, thyroid function profile, and illness severity score were recorded.

resultsMedian urine dipstick protein concentration to USG ratio and number of dogs having a ratio ≥1.5 were significantly higher for dogs with mucocele formation compared to control dogs. Proteinuria was not significantly associated with CBC or serum biochemistry profile abnormalities but increased in relation to severity of illness. CONCLUSIONS AND CLINICAL IMPORTANCE: Gallbladder mucocele formation is significantly associated with proteinuria in dogs. Diagnosis and treatment of proteinuria in dogs with mucocele formation might minimize long term kidney morbidity in these patients.

Indexed as

Dog DiseasesMucoceleAnimalsCase-Control StudiesDogsGallbladderProteinuriaRetrospective Studiescaninedipstickglomerular diseaseurinalysis

Identifiers

PMID33547696
PMCPMC7995360
OpenAlexW3129091773

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.