Evidence map›Paper›PMID 33547694›Full record

Trial reportHuman brain mapping2021

Neural changes following equine-assisted therapy for posttraumatic stress disorder: A longitudinal multimodal imaging study.

Xi Zhu, Benjamin Suarez-Jimenez, Sigal Zilcha-Mano, Amit Lazarov, Shay Arnon, Ari L Lowell, Maja Bergman, Matthew Ryba, Allan J Hamilton, Jane F Hamilton and 4 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05298397 (Pilot Study Examining Adaptation of EAT-PTSD), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05298397 naterminatednot on this mapstarted 2022, after this paper: background citation

Pilot Study Examining Adaptation of EAT-PTSD (the MOW Protocol) for Anxious Youth

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2022 to 2022Enrolled4ConditionsAnxiety Disorder of Childhood or AdolescenceArmsEAT-PTSD adapted for youth for anxiety
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Xi ZhuDepartment of Psychiatry, Columbia University, New York, New York, USA.ORCID 0000-0002-9724-7231
Benjamin Suarez-JimenezDepartment of Psychiatry, Columbia University, New York, New York, USA.
Sigal Zilcha-ManoDepartment of Psychology, University of Haifa, Haifa, Israel.
Amit LazarovDepartment of Psychiatry, Columbia University, New York, New York, USA.
Shay ArnonNew York State Psychiatric Institute, New York, New York, USA.
Ari L LowellDepartment of Psychiatry, Columbia University, New York, New York, USA.
Maja BergmanNew York State Psychiatric Institute, New York, New York, USA.
Matthew RybaNew York State Psychiatric Institute, New York, New York, USA.
Allan J HamiltonThe University of Arizona Health Sciences, Tucson, Arizona, USA.
Jane F HamiltonRancho Bosque Equestrian Center of Excellence, House Hamilton Business Group, PLC, Tucson, Arizona, USA.
J Blake TurnerDepartment of Psychiatry, Columbia University, New York, New York, USA.
John C MarkowitzDepartment of Psychiatry, Columbia University, New York, New York, USA.
Prudence W FisherDepartment of Psychiatry, Columbia University, New York, New York, USA.
Yuval NeriaDepartment of Psychiatry, Columbia University, New York, New York, USA.
New York Psychoanalytic Society and Institute · USColumbia University Irving Medical Center · USTel Aviv University · ILUnited States Equestrian Federation · USUniversity of Arizona · USUniversity of Haifa · IL

Funding

Identification of Distinct Multimodal Biotypes of PTSD Using Data Driven Approach: A Multisite Big Data StudyK01MH122774 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI ZHU, XI · 2021 to 2024
$705k
NIMH NIH HHS K01 MH122774
6 · The paper itself

Abstract

backgroundWhile effective treatments for posttraumatic stress disorder (PTSD) exist, many individuals, including military personnel and veterans fail to respond to them. Equine-assisted therapy (EAT), a novel PTSD treatment, may complement existing PTSD interventions. This study employs longitudinal neuro-imaging, including structural magnetic resonance imaging (sMRI), resting state-fMRI (rs-fMRI), and diffusion tensor imaging (DTI), to determine mechanisms and predictors of EAT outcomes for PTSD.

methodNineteen veterans with PTSD completed eight weekly group sessions of EAT undergoing multimodal MRI assessments before and after treatment. Clinical assessments were conducted at baseline, post-treatment and at 3-month follow-up.

resultsAt post-treatment patients showed a significant increase in caudate functional connectivity (FC) and reduction in the gray matter density of the thalamus and the caudate. The increase of caudate FC was positively associated with clinical improvement seen immediately at post-treatment and at 3-month follow-up. In addition, higher baseline caudate FC was associated with greater PTSD symptom reduction post-treatment.

conclusionsThis exploratory study is the first to demonstrate that EAT can affect functional and structural changes in the brains of patients with PTSD. The findings suggest that EAT may target reward circuitry responsiveness and produce a caudate pruning effect from pre- to post-treatment.

Indexed as

Caudate NucleusEquine-Assisted TherapyMagnetic Resonance ImagingNeuroimagingStress Disorders, Post-TraumaticAdultConnectomeDiffusion Tensor ImagingFemaleHumansLongitudinal StudiesMaleMiddle AgedMultimodal ImagingRewardTreatment Outcomeequine assisted therapyneuroimagingPTSDresting state fMRI

Identifiers

PMID33547694
PMCPMC7978114
OpenAlexW3127924216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.