Evidence map›Paper›PMID 33547632›Full record

ArticleCell stress & chaperones2021

Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability.

Jennifer Abrams, Taylor Arhar, Sue Ann Mok, Isabelle R Taylor, Martin Kampmann, Jason E Gestwicki

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stress & chaperones, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jennifer Abrams *Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94158, USA.
Taylor Arhar *Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94158, USA.
Sue Ann MokDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94158, USA.
Isabelle R TaylorDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94158, USA.
Martin KampmannInstitute for Neurodegenerative Disease, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA.
Jason E GestwickiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94158, USA. jason.gestwicki@ucsf.edu.ORCID 0000-0002-6125-3154
University of California, San Francisco · US

Funding

Molecular Chaperones and Small MoleculesR01NS059690 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason E Gestwicki · 2008 to 2026
$7.9M
Rewiring of the human protein homeostasis network in normal and disease contextsDP2GM119139 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN · 2015 to 2015
$2.3M
NIGMS NIH HHS DP2 GM119139NINDS NIH HHS R01 NS059690
6 · The paper itself

Abstract

Prion protein (PrP) adopts either a helical conformation (PrP

Indexed as

ProteostasisAnimalsCell Line, TumorCreutzfeldt-Jakob SyndromeHEK293 CellsHSP70 Heat-Shock ProteinsHumansMicePrion ProteinsProtein StabilityHSP70 Heat-Shock ProteinsPrion ProteinsChaperone networksDrug targetsHeat shock protein 70NeurodegenerationPrion protein (PrP)shRNA

Identifiers

PMID33547632
PMCPMC7925731
OpenAlexW3126708673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.