ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2021
Safety and Efficacy of Early (<4 Weeks of Illness) Endoscopic Transmural Drainage of Post-acute Pancreatic Necrosis Predominantly Located in the Body of the Pancreas.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05716633 (Tracking the ENcapsulation of Pancreatic Collections in Acute Necrotizing Pancreatitis. A Serial MRI Based Prospective Study), which is not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tracking the ENcapsulation of Pancreatic Collections in Acute Necrotizing Pancreatitis. A Serial MRI Based Prospective Study (MRI-ENCAP Study)
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- AEG-AESPANC-OPGE-SIED-SPG Ibero-Latin American Guidelines on Acute Pancreatitis (iLATAM-AP).United European gastroenterology journal · 2026Guideline
- Comparison of early and late drainage interventions in necrotizing pancreatitis: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- The short-term and long-term clinical outcomes from early versus delayed minimally invasive intervention for acute necrotic collections in necrotizing pancreatitis: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Pooled it
- Systematic review and meta-analysis of endoscopic ultrasound drainage for the management of fluid collections after pancreas surgery.Surgical endoscopy · 2022Pooled it
- The clinical outcome from early versus delayed minimally invasive intervention for infected pancreatic necrosis: a systematic review and meta-analysis.Journal of gastroenterology · 2022Pooled it
- Endoscopic drainage in necrotizing pancreatitis: Is the four-week cut-off still relevant?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Interventional Management of Acute Pancreatitis and Its Complications.Journal of clinical medicine · 2025Review
- Acute Necrotizing Pancreatitis-Advances and Challenges in Management for Optimal Clinical Outcomes.Medicina (Kaunas, Lithuania) · 2025Review
- Percutaneous Interventions and Necrosectomy in the Management of Peripancreatic Collections.Seminars in interventional radiology · 2025Review
- When to Intervene in Acute Necrotizing Pancreatitis: A Narrative Review of the Optimal Timing for Intervention Strategies.Medicina (Kaunas, Lithuania) · 2024Review
- Early Endoscopic Interventions for Pancreatic Necrosis: Indications, Technique, and Outcomes.Digestive diseases and sciences · 2024Review
- Therapeutic Endoscopic Ultrasound: Current Indications and Future Perspectives.GE Portuguese journal of gastroenterology · 2023Review
- Time to think prime times for treatment of necrotizing pancreatitis: Pendulum conundrum.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2023Review
- Early versus late endoscopic treatment of pancreatic necrotic collections: A systematic review and meta-analysis.Endoscopy international open · 2023Review
- Early versus delayed interventions for necrotizing pancreatitis: A systematic review and meta-analysis.DEN open · 2023Review
- Endoscopic step up: When and how.Surgery open science · 2022Article
- Early versus late drainage of pancreatic necrotic fluid collections: a systematic review and meta-analysis.Annals of gastroenterologyArticle
- Consensus guidelines on the diagnosis and treatment of pancreatic pseudocyst and walled-off necrosis from a Chinese multiple disciplinary team expert panel.Endoscopic ultrasoundArticle
- Lumen-apposing metal stents versus double pigtail plastic stents for early (<4 weeks of illness) endoscopic transluminal drainage of pancreatic necrotic collections.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic transmural drainage is usually not performed for pancreatic necrotic collection (PNC) < 4 weeks after onset of acute necrotizing pancreatitis (ANP) because of lack of encapsulating wall and increased risk of complications.
objectiveStudy safety and efficacy of early (<4 weeks) endoscopic transluminal drainage in patients with symptomatic PNC.
methodsRetrospective analysis of data base of patients with PNC treated with endoscopic transmural drainage within 4 weeks of onset of ANP (early drainage) was done. The outcomes and complications were compared with patients with PNC who underwent delayed endoscopic drainage (≥4 weeks of onset of ANP).
resultsThirty-four patients (26 males; mean age: 35.9 ± 8.6 years) underwent early and 136 patients (115 males; mean age: 37.9 ± 9.4 years) underwent delayed endoscopic drainage. The PNC was significantly larger (12.3 ± 2.1 cm vs 10.5 ± 2.7 cm, p <0.001) with increased solid component (47.7 ± 8.9% vs 28.3 ± 11.7%, p <0.001) in the early group. Clinical success was achieved in 94% patients in the early group and all patients in the delayed group. Direct endoscopic necrosectomy was performed more frequently in the early group (50% vs 7.4%; p<0.001). There was increased mortality (5.7% vs 0%), need for rescue surgical necrosectomy (5.7% vs 0%), and clinically significant bleeding (20% vs 1.5%, p<0.001) in the early group as compared to the delayed group.
conclusionEarly endoscopic drainage of PNC is feasible and seems to be safe as well as effective but is associated with increased risk of complications as compared to delayed drainage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.