Evidence map›Paper›PMID 33547576›Full record

ReviewJournal of general internal medicine2021

Routine Screening for Transgender and Gender Diverse Adults Taking Gender-Affirming Hormone Therapy: a Narrative Review.

Sean J Iwamoto, Frances Grimstad, Michael S Irwig, Micol S Rothman

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of general internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Hormone therapy and cancer risks in transgender people: a systematic review.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025
    Pooled it
  2. Oncological needs in transgender patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Gender-affirming hormonal therapy for transgender and gender-diverse people-A narrative review.Best practice & research. Clinical obstetrics & gynaecology · 2023
    Review
  9. Cardiovascular disease risk in the transgender population.Archivos de cardiologia de Mexico · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Sean J IwamotoDivision of Endocrinology, Metabolism & Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, 12801 E 17th Ave, Aurora, CO, 80045, USA. sean.iwamoto@cuanschutz.edu.ORCID 0000-0002-7316-8256
Frances GrimstadDivision of Gynecology, Department of Surgery, Boston Children's Hospital, Boston, 02115, MA, USA.
Michael S IrwigDivision of Endocrinology, Beth Israel Deaconess Medical Center, Boston, 02215, MA, USA.
Micol S RothmanDivision of Endocrinology, Metabolism & Diabetes, Department of Medicine, University of Colorado, Anschutz Medical Campus, 12801 E 17th Ave, Aurora, CO, 80045, USA.
Beth Israel Deaconess Medical Center · USBoston University · USUniversity of Colorado Health · USUniversity of Colorado Hospital · US

Funding

UCHSC: Building Interdisciplinary Research Careers in Women's HealthK12HD057022 · NICHD · UNIVERSITY OF COLORADO DENVER · PI REGENSTEINER, JUDITH G., SANTORO, NANETTE F. · 2007 to 2023
$8.5M
NICHD NIH HHS K12 HD057022
6 · The paper itself

Abstract

Despite the growing number of adult transgender and gender diverse (TGD) patients seeking health services, there are many unknowns regarding how routine screening recommendations should be applied to TGD persons receiving gender-affirming hormone therapy (GAHT). Patients taking GAHT may have disease risks that differ from what is expected based on their sex assigned at birth or affirmed gender identity. We discuss two patient cases, one transgender man and one transgender woman who present for routine medical care, to review several conditions that may be impacted by the hormones utilized in masculinizing and feminizing GAHT and for which screening recommendations are available for TGD adults: cardiovascular risk factors, osteoporosis, breast cancer, cervical cancer, and prostate cancer. We reviewed the TGD-specific screening recommendations from several major medical organizations and programs and found them to be largely based upon expert opinion due to a lack of evidence. The goal of this narrative review is to assist healthcare professionals in counseling and screening their TGD patients when and where appropriate. Not all TGD adults have the ability or need to receive routine medical care from a specialized TGD health clinic; therefore, it is essential for all healthcare professionals involved in routine and gender-affirming care to have knowledge about these conditions and screenings.

Indexed as

Transgender PersonsTranssexualismAdultFemaleGender IdentityHormonesHumansMaleMass ScreeningHormonescancercardiovascular diseaseosteoporosisscreeningtransgender

Identifiers

PMID33547576
PMCPMC8131455
OpenAlexW3127249075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.