Evidence map›Paper›PMID 33547566›Full record

ArticleTissue engineering and regenerative medicine2021

Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing.

June Seok Heo, Sinyoung Kim, Chae Eun Yang, Youjeong Choi, Seung Yong Song, Hyun Ok Kim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering and regenerative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
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  14. Extracellular vesicles: innovative cell-free solutions for wound repair.Frontiers in bioengineering and biotechnology · 2025
    Review
  15. Exosomes from Different Sources in Promoting Wound Healing.Recent advances in drug delivery and formulation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

June Seok HeoCell Therapy Center, Severance Hospital, Seoul, 03722, Republic of Korea.
Sinyoung KimDepartment of Laboratory Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Chae Eun YangDepartment of Plastic Surgery, Severance Christian Hospital, Wonju, 26426, Republic of Korea.
Youjeong ChoiCell Therapy Center, Severance Hospital, Seoul, 03722, Republic of Korea.
Seung Yong SongDepartment of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea. PSSYSONG@yuhs.ac.
Hyun Ok KimCell Therapy Center, Severance Hospital, Seoul, 03722, Republic of Korea. HYUNOK1019@yuhs.ac.
Yonsei University · KRSeverance Hospital · KRWonju Severance Christian Hospital · KR

Funding

National Research Foundation of Korea 2019R1C1C1007036
6 · The paper itself

Abstract

backgroundHuman adipose-derived mesenchymal stem cells (AMSCs) are an attractive resource for wound healing because their regenerative capacity improves injury repair. Recently, stem cell-derived exosomes have been shown to play a positive role in stem cell-based therapies. However, the effects of exosomes derived from AMSCs (AEXOs) on wound healing are unclear. In this study, we aimed to examine the role of AEXOs in attenuating inflammation and explore their effects in normal wound healing.

methodsWe isolated exosomes from AMSCs and established a cellular model of inflammation by treatment with the inflammatory cytokines, interferon gamma and tumor necrosis factor alpha, to determine whether AEXOs can inhibit inflammation. We examined the wound healing effects of AEXOs in in vitro wound healing models and performed a miRNA array to understand the role of AEXOs in inflammation and wound healing.

resultsA significant difference was observed in wound closure and the expression of anti-inflammatory and wound-healing-related factors between control and AEXO-treated cells.

conclusionOur results showed that besides alleviating the inflammation response, AEXOs also promote wound healing. Thus, AEXOs represent a novel, stem-cell-based, therapeutic strategy for wound healing.

Indexed as

ExosomesMesenchymal Stem CellsMicroRNAsAdipose TissueHumansWound HealingMicroRNAsAdipose-derived stem cellsExosomesInflammationWound healing

Identifiers

PMID33547566
PMCPMC8325736
OpenAlexW3126363283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.