Evidence map›Paper›PMID 33547553›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Use of radiomics based on

Yi Zhou, Xue-Lei Ma, Ting Zhang, Jian Wang, Tao Zhang, Rong Tian

Abstract read
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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Machine Learning-Driven radiomics on 18 F-FDG PET for glioma diagnosis: a systematic review and meta-analysis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
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  8. Can radiomics signatures and machine learning methods reinforce the revived role ofAsia Oceania journal of nuclear medicine & biology · 2026
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  9. Clinical study ofPeerJ · 2026
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  16. ExplainableJournal of cancer research and clinical oncology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi ZhouDepartment of Nuclear Medicine, West China Hospital, Sichuan University, 37# GuoXueLane, Chengdu, 610041, China.
Xue-Lei MaDepartment of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37# GuoXueLane, Chengdu, 610041, China.
Ting ZhangWest China School of Medicine, West China Hospital, Sichuan University, 37# GuoXueLane, Chengdu, 610041, China.
Jian WangSchool of Computer Science, Nanjing University of Science and Technology, No. 200, Xiaolinwei Road, Nanjing, 210094, China.
Tao ZhangWest China School of Medicine, West China Hospital, Sichuan University, 37# GuoXueLane, Chengdu, 610041, China.
Rong TianDepartment of Nuclear Medicine, West China Hospital, Sichuan University, 37# GuoXueLane, Chengdu, 610041, China. rongtiannuclear@126.com.ORCID http://orcid.org/0000-0002-5191-9004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was designed and performed to assess the ability of

methodsA total of 769 patients pathologically diagnosed with primary or metastatic lung cancers were enrolled. We used the LIFEx package to extract radiological features from semiautomatically segmented PET and CT images within the same volume of interest. Patients were randomly distributed in training and validation sets. Through the evaluation of five feature selection methods and nine classification methods, discriminant models were established. The robustness of the procedure was controlled by tenfold cross-validation. The model's performance was evaluated using the area under the receiver operating characteristic curve (AUC).

resultsBased on the radiomics features extracted from PET and CT images, forty-five discriminative models were established. Combined with appropriate feature selection methods, most classifiers showed excellent discriminative ability with AUCs greater than 0.75. In the differentiation between primary and metastatic lung lesions, the feature selection method gradient boosting decision tree (GBDT) combined with the classifier GBDT achieved the highest classification AUC of 0.983 in the PET dataset. In contrast, the feature selection method eXtreme gradient boosting combined with the classifier random forest (RF) achieved the highest AUC of 0.828 in the CT dataset. In the discrimination between squamous cell carcinoma and adenocarcinoma, the combination of GBDT feature selection method with GBDT classification had the highest AUC of 0.897 in the PET dataset. In contrast, the combination of the GBDT feature selection method with the RF classification had the highest AUC of 0.839 in the CT dataset. Most of the decision tree (DT)-based models were overfitted, suggesting that the classification method was not appropriate for practical application.

conclusion

Indexed as

Fluorodeoxyglucose F18Positron Emission Tomography Computed TomographyClinical Decision-MakingHumansLungMachine LearningRetrospective StudiesFluorodeoxyglucose F18Lung cancerLung metastasisMachine learningPositron emission tomography/computed tomographyRadiomicsSolitary pulmonary lesion

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.