ArticleEJNMMI physics2021
Use of population input functions for reduced scan duration whole-body Patlak
Article in EJNMMI physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Realization of long axial field-of-view PET technology in the clinic and research environment.The British journal of radiology · 2026Review
- Patlak-PBNT: a simple population-based Patlak model to generate [EJNMMI physics · 2026Article
- Fast 4D-PET parametric imaging computation at the whole field of view level: Reliability under simulated conditions of PET KinetiX, a dedicated software solution.European journal of nuclear medicine and molecular imaging · 2025Article
- Feasibility of simplified Patlak parametric imaging with scaled population-based input function on pancreatic cancer.EJNMMI physics · 2025Article
- Total-Body Parametric Imaging Using Relative Patlak Plot.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Clinical feasibility study of early 30-minute dynamic FDG-PET scanning protocol for patients with lung lesions.EJNMMI physics · 2024Article
- Clinical application of a population-based input function (PBIF) for a shortened dynamic whole-body FDG-PET/CT protocol in patients with metastatic melanoma treated by immunotherapy.EJNMMI physics · 2023Article
- Review
- Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Review
- Comparison of cardiac image-derived input functions for quantitative whole body [Frontiers in physiology · 2023Article
- Shortened duration whole bodyEJNMMI physics · 2022Article
- Comparison between a dual-time-window protocol and other simplified protocols for dynamic total-bodyEJNMMI physics · 2022Article
- Clinical validation of a population-based input function for 20-min dynamic whole-bodyEJNMMI physics · 2022Article
- Short-time-window Patlak imaging using a population-based arterial input function and optimized Bayesian penalized likelihood reconstruction: a feasibility study.EJNMMI research · 2022Article
- Optimal imaging time points considering accuracy and precision of Patlak linearization forEJNMMI research · 2022Article
- Can Dynamic Whole-Body FDG PET Imaging Differentiate between Malignant and Inflammatory Lesions?Life (Basel, Switzerland) · 2022Article
- Whole-Body Parametric Imaging ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Population-based input function (PBIF) applied to dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition.Frontiers in nuclear medicine · 2022Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-body Patlak images can be obtained from an acquisition of first 6 min of dynamic imaging over the heart to obtain the arterial input function (IF), followed by multiple whole-body sweeps up to 60 min pi. The use of a population-averaged IF (PIF) could exclude the first dynamic scan and minimize whole-body sweeps to 30-60 min pi. Here, the effects of (incorrect) PIFs on the accuracy of the proposed Patlak method were assessed. In addition, the extent of mitigating these biases through rescaling of the PIF to image-derived IF values at 30-60 min pi was evaluated.
methodsUsing a representative IF and rate constants from the literature, various tumour time-activity curves (TACs) were simulated. Variations included multiplication of the IF with a positive and negative gradual linear bias over 60 min of 5, 10, 15, 20, and 25% (generating TACs using an IF different from the PIF); use of rate constants (K
resultsPercentage bias in K
conclusionsSimulations suggest that scaling of a (possibly incorrect) PIF to IF values seen in whole-body dynamic imaging from 30 to 60 min pi can provide accurate Ki estimates. Consequently, dynamic Patlak imaging protocols may be performed for 30-60 min pi making whole-body Patlak imaging clinically feasible.
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