ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2021
Antibacterial hydrogel coating in joint mega-prosthesis: results of a comparative series.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Comparative effectiveness of antimicrobial implant surface coatings in preventing orthopaedic implant-associated infections: a network meta-analysis.Archives of orthopaedic and trauma surgery · 2026Pooled it
- Use of a Bioresorbable Antibacterial Coating (DACAntibiotics (Basel, Switzerland) · 2026Article
- Early Experience With Defensive Antibacterial Coating (DAC®) Hydrogel in High-Risk Orthopaedic Implant Surgery.Cureus · 2026Article
- Biomaterial-Driven Modulation of Macrophage Polarization in an Experimental Environment of Implant-Associated Infection Mediated byJournal of functional biomaterials · 2026Review
- How to Treat and Reconstruct the Pelvis After Chondrosarcoma Resection: Indications and Results at Medium- and Long-term in a Series of 34 patients.Indian journal of surgical oncology · 2026Article
- Bioabsorbable Hydrogel Coating for Infection Prevention in Fracture Fixation: A Retrospective Matched Case-Control Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review.Pathogens (Basel, Switzerland) · 2026Review
- Effects of antibiotics encapsulated in hyaluronic acid hydrogels on different osteogenic cells and bacteria.Cell and tissue research · 2026Article
- DACBiomedicines · 2025Article
- Current Concepts of Local Antibiotic Delivery in Bone and Joint Infections-A Narrative Review of Techniques and Clinical Experiences.Microorganisms · 2025Review
- Defensive antibacterial coating in orthopaedic surgery: Current evidence and future direction.World journal of orthopedics · 2025Review
- Antibacterial hydrogel coating is associated with lower complication risks after complex high-risk primary and cementless hip revision arthroplasty : a retrospective matched cohort study.Bone & joint open · 2025Article
- The Efficacy of Defensive Antibacterial Coating (DAC™) Periprosthetic Joint Infection Prevention in the Hip: A Systematic Review.Journal of clinical medicine · 2025Review
- Antibiotic-Loaded Hydrogel for the Treatment of Lower-Limb Fracture-Related Infections: A Single Center's Multidisciplinary Experience.Gels (Basel, Switzerland) · 2024Article
- Characteristics and Epidemiology of Megaprostheses Infections: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Recent Advancements in Hydrogel Biomedical Research in Italy.Gels (Basel, Switzerland) · 2024Review
- Topical Application of Vancomycin Powder to Prevent Infections after Massive Bone Resection and the implantation of Megaprostheses in Orthopaedic Oncology Surgery.Malaysian orthopaedic journal · 2024Article
- Implant Surface Technologies to Prevent Surgical Site Infections in Spine Surgery.International journal of spine surgery · 2023Article
- The Intraoperative Use of Defensive Antibacterial Coating (DACMaterials (Basel, Switzerland) · 2023Review
- Clinical exploration of the international society of limb salvage classification of endoprosthetic failure using Henderson in the application of 3D-printed pelvic tumor prostheses.Frontiers in oncology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeJoint mega-prosthesis after bone tumors, severe trauma or infection is associated with high rates of post-surgical septic complications. A fast-resorbable antibacterial hydrogel coating (DAC®, Defensive Antibacterial Coating) has previously been shown to be able to significantly reduce surgical site infection in various clinical settings. Aim of the present study was to evaluate the safety and efficacy of the DAC hydrogel coating to prevent early periprosthetic joint infection after joint mega-prosthesis.
methodsIn this three-centers, case-control study, 43 patients, treated with an antibacterial hydrogel coated mega-prosthesis for oncological (N = 39) or non-oncological conditions (N = 4), were retrospectively compared with 43 matched controls, treated with mega-implants without the coating. Clinical, laboratory and radiographic examinations were performed to evaluate the occurrence of post-surgical infection, complications and adverse events.
resultsAt a mean follow-up of 2 years, no evidence of infection or adverse events were observed in the DAC-treated group, compared to six cases of post-surgical infection in the control group.
conclusionThis matched case-control study shows that a fast-resorbable, antibiotic-loaded coating can be safely used to protect joint mega-prosthesis, providing a reduction of early surgical site infections with no side effects. Larger prospective trials with longer follow-ups are warranted to confirm this report.
trial registrationRS1229/19 (Regina Elena National Cancer Institute Experimental Registry Number).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.