Evidence map›Paper›PMID 33547496›Full record

ReviewBrain structure & function2021

Exploring the secrets of brain transcriptional regulation: developing methodologies, recent significant findings, and perspectives.

Zhe Ding, Luyun Sun, Cen Yang, Aihua Liu, Fukai Bao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhe DingDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, 650500, China.
Luyun SunYunnan Province Key Laboratory for Tropical Infectious Diseases, Kunming Medical University, Kunming, 650500, China.
Cen YangDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, 650500, China.
Aihua LiuDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, 650500, China. liuaihua@kmmu.edu.cn.
Fukai BaoDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, 650500, China. baofukai@kmmu.edu.cn.ORCID http://orcid.org/0000-0003-2652-6660
Kunming Medical University · CN

Funding

Joint Special Project of Yunnan Science and Technology Department and Kunming Medical University 2019FE001-002National Natural Science Foundation of China 31560051National Natural Science Foundation of China 81560596National Natural Science Foundation of China 81860644
6 · The paper itself

Abstract

Exploring and revealing the secret of the function of the human brain has been the dream of mankind and science. Delineating brain transcriptional regulation has been extremely challenging, but recent technological advances have facilitated a deeper investigation of molecular processes in the brain. Tracing the molecular regulatory mechanisms of different gene expression profiles in the brain is divergent and has made it possible to connect spatial and temporal variations in gene expression to distributed properties of brain structure and function. Here, we review the molecular diversity of the brain among rodents, non-human primates and humans. We also discuss the molecular mechanism of non-coding DNA/RNA at the transcriptional/post-transcriptional level based on recent technical advances to highlight an improved understanding of the complex transcriptional network in the brain. Spatiotemporal and single-cell transcriptomics have attempted to gain novel insight into the development and evolution of the brain as well as the progression of human diseases. Although it is clear that the field is developing and challenges remain to be resolved, the impressive recent progress provides a solid foundation to better understand the brain and evidence-based recommendations for the diagnosis and treatment of brain diseases.

Indexed as

Gene Expression RegulationGene Regulatory NetworksTranscriptomeAnimalsBrainGene Expression ProfilingHumansBrain transcriptomeNon-coding sequenceSingle-cell sequenceSpatiotemporal transcriptomeTranscriptional regulation

Identifiers

PMID33547496
OpenAlexW3126349576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.