Evidence map›Paper›PMID 33547487›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021

The independent and interactive associations of physical activity intensity and vitamin D status with bone mineral density in prepubertal children: the PANIC Study.

A M Constable, D Vlachopoulos, A R Barker, S A Moore, S Soininen, E A Haapala, J Väistö, K Westgate, S Brage, A Mahonen and 1 more

Registry-linked trialAbstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01803776 (The Physical Activity and Nutrition in Children), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01803776 naunknown statusnot on this map

The Physical Activity and Nutrition in Children (PANIC) Study

TypeinterventionalSponsorUniversity of Eastern FinlandRan2007 to 2023Enrolled504ConditionsOverweight, Glucose Metabolism Disorders, Lipid Metabolism Disorders, Blood PressureArmslifestyle counseling
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

A M ConstableChildren's Health and Exercise Research Centre, University of Exeter, Exeter, UK.
D VlachopoulosChildren's Health and Exercise Research Centre, University of Exeter, Exeter, UK. d.vlachopoulos@exeter.ac.uk.ORCID http://orcid.org/0000-0003-1556-715X
A R BarkerChildren's Health and Exercise Research Centre, University of Exeter, Exeter, UK.
S A MooreSchool of Health and Human Performance, Dalhousie University, Halifax, Canada.
S SoininenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
E A HaapalaInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
J VäistöInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
K WestgateMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
S BrageMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
A MahonenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
T A LakkaInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
University of Eastern Finland · FIUniversity of Cambridge · GBUniversity of Exeter · GBDalhousie University · CA

Funding

Medical Research Council MC_UU_00006/4NIHR Cambridge Biomedical Research Centre IS-BRC-1215-20014UK Medical Research Council MC_UU_12015/3
6 · The paper itself

Abstract

It is unclear how physical activity intensity and vitamin D status are related to bone health in prepubertal children. We found positive associations between vitamin D status and moderate-to-vigorous physical activity with bone in boys and girls. This highlights the importance of lifestyle factors for skeletal health prepuberty.

introductionThe sex-specific independent and interactive associations of physical activity (PA) intensity and serum 25-hydroxyvitamin D (25(OH)D) levels with areal bone mineral density (aBMD) were investigated in prepubertal children.

methodsThe participants were 366 prepubertal Finnish children (190 boys, 176 girls) aged 6-8 years. Linear regression analysed the associations of sedentary time (ST), light PA (LPA), moderate PA (MPA), moderate-to-vigorous PA (MVPA) and vigorous PA (VPA) measured by accelerometery, and serum 25(OH)D with total body less head (TBLH) and lower-limb aBMD, measured by dual-energy X-ray absorptiometry.

resultsThere was no interaction between PA intensity or serum 25(OH)D and sex with aBMD. MPA and MVPA were positively associated with TBLH and lower-limb aBMD (β = 0.11, 95% CI 0.02-0.20, p = 0.01). Serum 25(OH)D was positively associated with TBLH and lower-limb aBMD (β = 0.09, 95% CI 0.01-0.18, p = 0.03). There were no interactions between PA intensity and serum 25(OH)D with aBMD.

conclusionVitamin D status, MPA and MVPA levels in active prepubertal children were positively associated with aBMD. The influence of MVPA is due to the MPA component, though our findings regarding the role of VPA should be interpreted with caution, as shorter accelerometer epochs are needed to more accurately assess VPA. This study adds evidence to the promotion of MPA and behaviours to encourage optimal vitamin D status in supporting skeletal health in childhood, though these need not be used in conjunction to be beneficial, and a sex-specific approach is not necessary in prepubertal children. TRIAL REGISTRATION NUMBER: NCT01803776 . Date of registration: 4/03/2013.

Indexed as

Bone DensityExerciseAbsorptiometry, PhotonChildFemaleHumansMaleSedentary BehaviorVitamin DVitamin DAccelerometeryBone massChildhoodDXAGrowth

Identifiers

PMID33547487
OpenAlexW3127692037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.