Evidence map›Paper›PMID 33547403›Full record

ArticleCommunications biology2021

Components of a Neanderthal gut microbiome recovered from fecal sediments from El Salt.

Simone Rampelli, Silvia Turroni, Carolina Mallol, Cristo Hernandez, Bertila Galván, Ainara Sistiaga, Elena Biagi, Annalisa Astolfi, Patrizia Brigidi, Stefano Benazzi and 5 more

Abstract readHistorical Article
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Journal of oral microbiology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Metagenomic analysis of Ancient Egyptian canopic jars.American journal of biological anthropology · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Simone Rampelli *Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, Bologna, Italy.ORCID 0000-0002-5655-6695
Silvia Turroni *Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, Bologna, Italy.ORCID 0000-0003-2345-9482
Carolina MallolDepartment of Geography and History, University of La Laguna, Campus de Guajara, La Laguna, Tenerife, Spain.
Cristo HernandezDepartment of Geography and History, University of La Laguna, Campus de Guajara, La Laguna, Tenerife, Spain.
Bertila GalvánDepartment of Geography and History, University of La Laguna, Campus de Guajara, La Laguna, Tenerife, Spain.
Ainara SistiagaEarth, Atmospheric and Planetary Sciences Department, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA, USA.
Elena BiagiUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, Bologna, Italy.
Annalisa Astolfi"Giorgio Prodi" Cancer Research Center, University of Bologna, Via Massarenti 11, Bologna, Italy.
Patrizia BrigidiDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, Bologna, Italy.
Stefano BenazziDepartment of Cultural Heritage, University of Bologna, Via degli Ariani 1, Ravenna, Italy.
Cecil M LewisLaboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, 101 David L. Boren Blvd, Norman, OK, USA.
Christina WarinnerDepartment of Anthropology, University of Oklahoma, 455W Lindsey St, Norman, OK, USA.ORCID 0000-0002-4528-5877
Courtney A HofmanLaboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, 101 David L. Boren Blvd, Norman, OK, USA.ORCID 0000-0002-6808-3370
Stephanie L SchnorrKonrad Lorenz Institute for Evolution and Cognition Research, Martinstraße 12, Klosterneuburg, Austria. stephanie.schnorr@kli.ac.at.ORCID 0000-0002-3742-0565
Marco CandelaUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, Bologna, Italy. marco.candela@unibo.it.ORCID 0000-0001-7420-790X

Funding

Microbial Ecologies of Indigenous CommunitiesR01GM089886 · NIGMS · UNIVERSITY OF OKLAHOMA · PI LAWSON, PAUL ALAN, LEWIS, CECIL M · 2011 to 2019
$2.4M
NIGMS NIH HHS R01 GM089886
6 · The paper itself

Abstract

A comprehensive view of our evolutionary history cannot ignore the ancestral features of our gut microbiota. To provide some glimpse into the past, we searched for human gut microbiome components in ancient DNA from 14 archeological sediments spanning four stratigraphic units of El Salt Middle Paleolithic site (Spain), including layers of unit X, which has yielded well-preserved Neanderthal occupation deposits dating around 50 kya. According to our findings, bacterial genera belonging to families known to be part of the modern human gut microbiome are abundantly represented only across unit X samples, showing that well-known beneficial gut commensals, such as Blautia, Dorea, Roseburia, Ruminococcus, Faecalibacterium and Bifidobacterium already populated the intestinal microbiome of Homo since as far back as the last common ancestor between humans and Neanderthals.

Indexed as

Gastrointestinal MicrobiomeAnimalsArchaeologyDNA, AncientEcosystemFecesFossilsGeologic SedimentsHistory, AncientHumansMetagenomicsNeanderthalsSequence Analysis, DNASpainDNA, Ancient

Identifiers

PMID33547403
PMCPMC7864912

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.