ArticleScientific reports2021
Impaired inhibition of return during free-viewing behaviour in patients with schizophrenia.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- The effects of increasing and decreasing dopamine on inhibition of return: a psychopharmacological investigation.Experimental brain research · 2026Article
- Eye Movement Patterns as Robust Biomarkers for Schizophrenia Identification Using a Novel Data Transformation Approach.Journal of eye movement research · 2026Article
- Schizophrenia recognition via eye movement features in video paradigm.European archives of psychiatry and clinical neuroscience · 2026Article
- Modulating effect of positive emotion arousal on inhibition of return in schizophrenia.BMC psychiatry · 2026Article
- Computational modeling of visual salience alteration and its application to eye-movement data.Frontiers in neuroscience · 2025Article
- Modulating effect of emotional arousal intensity on selective attention in schizophrenia.Frontiers in psychiatry · 2025Article
- Tablet-Based Cognitive and Eye Movement Measures as Accessible Tools for Schizophrenia Assessment: Multisite Usability Study.JMIR mental health · 2024Article
- Visual salience is affected in participants with schizophrenia during free-viewing.Scientific reports · 2024Article
- Neural Correlates of Variation in Personal Space and Social Functioning in Schizophrenia and Healthy Individuals.Schizophrenia bulletin · 2022Article
- Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy.Journal of neurology · 2022Article
- Trends in big data analyses by multicenter collaborative translational research in psychiatry.Psychiatry and clinical neurosciences · 2022Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia affects various aspects of cognitive and behavioural functioning. Eye movement abnormalities are commonly observed in patients with schizophrenia (SZs). Here we examined whether such abnormalities reflect an anomaly in inhibition of return (IOR), the mechanism that inhibits orienting to previously fixated or attended locations. We analyzed spatiotemporal patterns of eye movement during free-viewing of visual images including natural scenes, geometrical patterns, and pseudorandom noise in SZs and healthy control participants (HCs). SZs made saccades to previously fixated locations more frequently than HCs. The time lapse from the preceding saccade was longer for return saccades than for forward saccades in both SZs and HCs, but the difference was smaller in SZs. SZs explored a smaller area than HCs. Generalized linear mixed-effect model analysis indicated that the frequent return saccades served to confine SZs' visual exploration to localized regions. The higher probability of return saccades in SZs was related to cognitive decline after disease onset but not to the dose of prescribed antipsychotics. We conclude that SZs exhibited attenuated IOR under free-viewing conditions, which led to restricted scene scanning. IOR attenuation will be a useful clue for detecting impairment in attention/orienting control and accompanying cognitive decline in schizophrenia.
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