ArticleScientific reports2021
Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- A Sea Mud Feed Matrix Shapes Short-Term Dietborne Glyphosate Exposure in the Sea Cucumber (Animals : an open access journal from MDPI · 2026Article
- Exposomics as a discovery engine for emerging contaminants and hidden biological risks.Emerging contaminants · 2026Article
- Agricultural chemicals and gut microbiota dysbiosis: implications for the pathogenesis of inflammatory bowel disease.Frontiers in nutrition · 2026Review
- Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro.Nature microbiology · 2025Article
- Toxicological concerns regarding glyphosate, its formulations, and co-formulants as environmental pollutants: a review of published studies from 2010 to 2025.Archives of toxicology · 2025Review
- Occurrence and profiles of glyphosate and aminomethylphosphonic acid in paired urine and feces of humans, cats, and dogs.Environment international · 2025Article
- Associations between urine glyphosate levels and metabolic health risks: insights from a large cross-sectional population-based study.Environmental health : a global access science source · 2024Article
- Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication.ACS pharmacology & translational science · 2024Review
- Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure.Archives of toxicology · 2024Article
- Glyphosate-based herbicide metabolic profiles in human urine samples through proton nuclear magnetic resonance analysis.ADMET & DMPK · 2024Article
- Association between urinary glyphosate levels and hand grip strength in a representative sample of US adults: NHANES 2013-2014.Frontiers in public health · 2024Article
- Impact of glyphosate (RoundupGut microbes · 2023Review
- Salivary Metabolomic Signatures and Body Mass Index in Italian Adolescents: A Pilot Study.Journal of the Endocrine Society · 2023Article
- Associations between the Gut Microbiota, Urinary Metabolites, and Diet in Women during the Third Trimester of Pregnancy.Current developments in nutrition · 2023Article
- Biological effects of sub-lethal doses of glyphosate and AMPA on cardiac myoblasts.Frontiers in physiology · 2023Article
- Freshwater mussels and host fish gut microbe community composition shifts after agricultural contaminant exposure.Journal of applied microbiology · 2022Article
- Does Glyphosate Affect the Human Microbiota?Life (Basel, Switzerland) · 2022Article
- Comparison of untargeted and targeted perfluoroalkyl acids measured in adolescent girls.Chemosphere · 2022Article
- Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment.Frontiers in microbiology · 2022Review
- Direct Effects of Glyphosate onFrontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Glyphosate-based herbicides (GBHs) can disrupt the host microbiota and influence human health. In this study, we explored the potential effects of GBHs on urinary metabolites and their interactions with gut microbiome using a rodent model. Glyphosate and Roundup (equal molar for glyphosate) were administered at the USA glyphosate ADI guideline (1.75 mg/kg bw/day) to the dams and their pups. The urine metabolites were profiled using non-targeted liquid chromatography-high resolution mass spectrometry (LC-HRMS). Our results found that overall urine metabolite profiles significantly differed between dams and pups and between female and male pups. Specifically, we identified a significant increase of homocysteine, a known risk factor of cardiovascular disease in both Roundup and glyphosate exposed pups, but in males only. Correlation network analysis between gut microbiome and urine metabolome pointed to Prevotella to be negatively correlated with the level of homocysteine. Our study provides initial evidence that exposures to commonly used GBH, at a currently acceptable human exposure dose, is capable of modifying urine metabolites in both rat adults and pups. The link between Prevotella-homocysteine suggests the potential role of GBHs in modifying the susceptibility of homocysteine, which is a metabolite that has been dysregulated in related diseases like cardiovascular disease or inflammation, through commensal microbiome.
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