ArticleScientific reports2021
Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
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- From Agro-Waste to Therapeutic Potential: Spasmolytic Mechanisms ofPlants (Basel, Switzerland) · 2026Article
- Potentiation of the Pharmacological Effects of anPharmaceutics · 2026Article
- In Vitro Study on the Effects ofInternational journal of molecular sciences · 2026Article
- Exploring the valorization of green leaves accumulated as agricultural waste into plant-based fermented juices.Frontiers in nutrition · 2026Article
- Southern Chilean Native Plants as Novel Sources of Antioxidant and Antibacterial Extracts.Antioxidants (Basel, Switzerland) · 2025Article
- Microfluidic Design of Ultradeformable Liposomes for Advanced Skin Delivery ofPharmaceutics · 2025Article
- The blueberry phyllosphere microbiota: tissue-specific core communities and their stability across cultivars and years.BMC plant biology · 2025Article
- A Review of Botany, Phytochemistry, and Biological Activities ofPlants (Basel, Switzerland) · 2025Review
- Encapsulation Processes: Valorization, Stabilization, and Commercialization of Active and Natural Compounds.Foods (Basel, Switzerland) · 2025Article
- Determination of the Polyphenol Composition of Raspberry Leaf Using LC-MS/MS.Molecules (Basel, Switzerland) · 2025Article
- Microencapsulation of Extracts of Strawberry (Molecules (Basel, Switzerland) · 2024Article
- Highly Specific Polyphenolic Colloids as Alternatives to Antimicrobials in Livestock Production.International journal of molecular sciences · 2024Article
- Article
- Monascus pigment prevent the oxidative cytotoxicity in myotube derived hydrogen peroxide.Journal of clinical biochemistry and nutrition · 2024Article
- Exploring Phenolic Compounds in Crop By-Products for Cosmetic Efficacy.International journal of molecular sciences · 2024Review
- The Effect of Phenolic-Rich Extracts ofNutrients · 2024Article
- Valorization of Agricultural By-Products (Foods (Basel, Switzerland) · 2024Article
- Green Approach to Enhance the Recovery of Polyphenols from Blackcurrant and Bilberry Leaves: Evaluation of Microwave-Assisted and Pressurized Liquid Extraction.Molecules (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccinum myrtillus L., Ribes nigrum L., Rubus fruticosus L., Fragaria vesca L. leaves are considered an agro-waste of the berry industry. Although numerous studies indicate fruit is a rich source of bioactive compounds, the authors prove leaves can also be a valuable source of compounds used in the pharmaceutical and cosmetic industries. The study attempts to assess and compare the antioxidant and cytotoxic properties of berry leaves extracts. The total phenolic compounds, flavonoids, anthocyanins and procyanidins content were determined. Antioxidant potential was evaluated using the DPPH radical scavenging method. Cytotoxicity studies were conducted to evaluate the effect of the extracts on the metabolism and proliferation of keratinocytes and fibroblasts in vitro. The effect on the migration capacity of these cells was also assessed. The obtained results show that the examined extracts are a source of valuable bioactive agents. All tested extracts show significant ability to remove free radicals in higher concentrations. Cytotoxicity assessments have shown that leaf extracts of the analyzed plants differ in cytotoxicity, both for keratinocytes and fibroblasts. The results of the assessment of cell migration capacity correlate with cytotoxicity tests, because the concentration of extracts showing cytotoxic activity towards the tested cells also inhibited their migration.
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