Evidence map›Paper›PMID 33547326›Full record

ArticleNPJ biofilms and microbiomes2021

Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking.

Lydia C Powell, Muthanna Abdulkarim, Joana Stokniene, Qiu E Yang, Timothy R Walsh, Katja E Hill, Mark Gumbleton, David W Thomas

Open access · goldAbstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  3. mSphere · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lydia C Powell *Advanced Therapies Group, Cardiff University School of Dentistry, Cardiff, UK. l.c.powell@swansea.ac.uk.ORCID http://orcid.org/0000-0002-8641-0160
Muthanna Abdulkarim *School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK. AbdulkarimMF@cardiff.ac.uk.ORCID http://orcid.org/0000-0001-5753-7261
Joana StoknieneAdvanced Therapies Group, Cardiff University School of Dentistry, Cardiff, UK.
Qiu E YangMedical Microbiology and Infectious Disease, School of Medicine, Cardiff University, Cardiff, UK.
Timothy R WalshMedical Microbiology and Infectious Disease, School of Medicine, Cardiff University, Cardiff, UK.
Katja E HillAdvanced Therapies Group, Cardiff University School of Dentistry, Cardiff, UK.ORCID http://orcid.org/0000-0002-8590-0117
Mark GumbletonSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
David W ThomasAdvanced Therapies Group, Cardiff University School of Dentistry, Cardiff, UK.
Cardiff University · GBSwansea University · GB

Funding

Medical Research Council MC-PC_17186Medical Research Council MC_PC_17186Medical Research Council MR/S013768/2
6 · The paper itself

Abstract

Novel therapeutics designed to target the polymeric matrix of biofilms requires innovative techniques to accurately assess their efficacy. Here, multiple particle tracking (MPT) was developed to characterize the physical and mechanical properties of antimicrobial resistant (AMR) bacterial biofilms and to quantify the effects of antibiotic treatment. Studies employed nanoparticles (NPs) of varying charge and size (40-500 nm) in Pseudomonas aeruginosa PAO1 and methicillin-resistant Staphylococcus aureus (MRSA) biofilms and also in polymyxin B (PMB) treated Escherichia coli biofilms of PMB-sensitive (PMB

Indexed as

BiofilmsDose-Response Relationship, DrugDrug Resistance, BacterialEscherichia coliMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMicrobial ViabilityMicroscopy, ConfocalNanoparticlesParticle SizePolymyxin BPseudomonas aeruginosaSingle Molecule ImagingPolymyxin B

Identifiers

PMID33547326
PMCPMC7864955
OpenAlexW3128921198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.