ArticleNPJ Parkinson's disease2021
The role of brain perivascular space burden in early-stage Parkinson's disease.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Glymphatic Dysfunction in Parkinson's Disease: A Systematic Review and Meta-Analysis of Neuroimaging Studies.Movement disorders clinical practice · 2026Pooled it
- A comprehensive framework for automated segmentation of perivascular spaces in brain MRI with the nnU-Net.Neuroradiology · 2026Article
- Higher glymphatic system activity is linked to longer prodromal stage in isolated REM sleep behavior disorder: a possible protective factor.NPJ Parkinson's disease · 2026Article
- Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.Signal transduction and targeted therapy · 2026Article
- Quantitative and Qualitative MRI Assessment of Perivascular Spaces in Parkinson's Disease Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Age- and sex-related glymphatic differences and hemispheric asymmetry in healthy adults at 7.0T magnetic resonance imaging.Psychoradiology · 2026Article
- Association Between Glymphatic Dysfunction and Anxiety in Parkinson's Disease: Insights from DTI-ALPS and Choroid Plexus Volume.Neuropsychiatric disease and treatment · 2026Article
- The association between enlarged perivascular spaces and muscle sympathetic nerve activity in normotensive and hypertensive humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- The influence of intermittent hypercapnia on cerebrospinal fluid flow and clearance in Parkinson's disease and healthy older adults.NPJ Parkinson's disease · 2025Article
- Association of MRI-Visible Perivascular Spaces with Early White Matter Injury.AJNR. American journal of neuroradiology · 2025Article
- Glymphatic Function in Prodromal Parkinson's Disease: Associations With Symptoms, Gray Matter Volume, and Phenoconversion Risk.European journal of neurology · 2025Article
- Independent Associations of Sleep and Walking with Cognition in Parkinson's Disease: A Perivascular Spaces Analysis.bioRxiv : the preprint server for biology · 2025Article
- Distribution of perivascular spaces distribution and relate to the clinical features of SCA3.Orphanet journal of rare diseases · 2025Article
- Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism.Scientific reports · 2025Observational
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- Waste clearance shapes aging brain health.Neuron · 2025Review
- Space exploration and risk of Parkinson's disease: a perspective review.NPJ microgravity · 2025Review
- Evaluation of the glymphatic system using the DTI-ALPS index in type 2 diabetes mellitus-induced cognitive impairment.Journal of clinical imaging science · 2025Article
- Remote Regulation of Molecular Diffusion in Extracellular Space of Parkinson's Disease Rat Model by Subthalamic Nucleus Deep Brain Stimulation.Cyborg and bionic systems (Washington, D.C.) · 2025Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
Abstract
Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on Parkinson's disease (PD) remains unclear. We aimed to investigate the clinical and neuroimaging significance of PVS in basal ganglia (BG) and midbrain in early-stage PD. We recruited 40 early-stage PD patients and 41 healthy controls (HCs). Both PVS number and volume were calculated to evaluate PVS burden on 7 T magnetic resonance imaging images. We compared PVS burden between PD and HC, and conducted partial correlation analysis between PVS burden and clinical and imaging features. PD patients had a significantly more serious PVS burden in BG and midbrain, and the PVS number in BG was significantly correlated to the PD disease severity and L-dopa equivalent dosage. The fractional anisotropy and mean diffusivity values of certain subcortical nuclei and white matter fibers within or nearby the BG and midbrain were significantly correlated with the ipsilateral PVS burden indexes. Regarding to the midbrain, the difference between bilateral PVS burden was, respectively, correlated to the difference between fiber counts of white fiber tract passing through bilateral substantia nigra in PD. Our study suggests that PVS burden indexes in BG are candidate biomarkers to evaluate PD motor symptom severity and aid in predicting medication dosage. And our findings also highlight the potential correlations between PVS burden and both grey and white matter microstructures.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.