ArticleNature communications2021
IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Stem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice.Nature communications · 2026Article
- Gastrointestinal acute graft versus host disease: a translational perspective from pathogenesis to precision prevention and treatment.Frontiers in immunology · 2026Review
- Intestinal epithelial Ceacam1 deficiency prevents steroid-refractory acute gut graft-versus-host disease.JCI insight · 2025Article
- [Effects of donor T cell stat3 deficiency on acute intestinal graft-versus-host disease in mice].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Graft-Versus-Host Disease Mouse Models: A Clinical-Translational Perspective.Methods in molecular biology (Clifton, N.J.) · 2025Review
- The Absence of IL-12Rβ2 Expression on Recipient Nonhematopoietic Cells Diminishes Acute Graft-versus-Host Disease in the Gastrointestinal Tract.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Biomarkers for early complications post hematopoietic cell transplantation: Insights and challenges.Frontiers in immunology · 2023Review
- Maternal consumption of a high-fat diet modulates the inflammatory response in their offspring, mediated by the M1 muscarinic receptor.Frontiers in immunology · 2023Article
- Effects of Immune Cells on Intestinal Stem Cells: Prospects for Therapeutic Targets.Stem cell reviews and reports · 2022Review
- Article
- Steroid-Refractory Gut Graft-Versus-Host Disease: What We Have Learned From Basic Immunology and Experimental Mouse Model.Frontiers in immunology · 2022Review
- Acute GVHD: think before you treat.Hematology. American Society of Hematology. Education Program · 2021Review
- Retinoic Acid Signaling Modulates Recipient Gut Barrier Integrity and Microbiota After Allogeneic Hematopoietic Stem Cell Transplantation in Mice.Frontiers in immunology · 2021Article
- Novel Insights Into the Mechanism of GVHD-Induced Tissue Damage.Frontiers in immunology · 2021Review
- The emerging roles of the gut microbiome in allogeneic hematopoietic stem cell transplantation.Gut microbesReview
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Qingxiao SongDiabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID 0000-0001-9243-5666
Xiaoning WangDiabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID 0000-0002-2472-4076
Xiwei WuDepartment of Integrative Genomics Core, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Tae Hyuk KangDepartment of Integrative Genomics Core, The Beckman Research Institute of City of Hope, Duarte, CA, USA.ORCID 0000-0001-9085-8139
Hanjun QinDepartment of Integrative Genomics Core, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Dongchang ZhaoThe Tisch Cancer Institute and Division of Hematology/Medical Oncology, The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
Robert R JenqDepartments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Marcel R M van den BrinkDepartment of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-0696-4401
Arthur D RiggsDiabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA.
Paul J MartinFred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9051-1215
Yuan-Zhong ChenFujian Medical University Center of Translational Hematology, Fujian Institute of Hematology, and Fujian Medical University Union Hospital, Fuzhou, China. chenyz@fjmu.edu.cn.ORCID 0000-0002-9411-1427
Defu ZengDiabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, USA. dzeng@coh.org.ORCID 0000-0001-9585-1411
City of Hope · USFujian Medical University · CNMemorial Sloan Kettering Cancer Center · USMount Sinai Hospital · USThe University of Texas MD Anderson Cancer Center · USUniversity of Washington · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTransgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3MT LYMPHOCYTE SUBSET FUNCTION POST-TRANSPLANTATIONP01CA023766 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SCHEINBERG, DAVID A · 1985 to 2023
$59.0MRole of autoreactivity in the pathogenesis of chronic GVHDR01AI066008 · NIAID · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI ZENG, DEFU · 2005 to 2020
$6.1MThe role of intestinal microbiota in graft-versus-host diseaseR01CA228308 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Philip L Lorenzi, Marcel R M van den Brink · 2018 to 2026
$5.2MThe role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2MPD-L1 interacts with CD80 and PD-1 to regulate GVHD and GVL activityR01CA228465 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI ZENG, DEFU · 2018 to 2022
$2.0MNCI NIH HHS P01 CA023766NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA228308NCI NIH HHS R01 CA228465NHLBI NIH HHS R01 HL123340NIAID NIH HHS R01 AI066008
Abstract
Efforts to improve the prognosis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) have suffered from poor understanding of its pathogenesis. Here we show that the pathogenesis of SR-Gut-aGVHD is associated with reduction of IFN-γ
Indexed as
AnimalsCD8-Positive T-LymphocytesCX3C Chemokine Receptor 1Disease Models, AnimalDysbiosisGastrointestinal MicrobiomeGene Expression RegulationGraft vs Host DiseaseInterferon-gammaInterleukin-17Interleukin-22InterleukinsIntestinesLymphocyte DepletionMaleMiceCX3C Chemokine Receptor 1Cx3cr1 protein, mouseIFNG protein, mouseIl17a protein, mouseInterferon-gammaInterleukin-17Interleukin-22InterleukinsPancreatitis-Associated ProteinsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReg3g protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.