ArticleNature communications2021
Phylogenetic analyses suggest centipede venom arsenals were repeatedly stocked by horizontal gene transfer.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Characterizing the evolution and potential function of eleven horizontally transferred genes in amphioxus.Communications biology · 2026Article
- Comparative analysis of 163 ant genomes reveals recurrent horizontal gene transfer from bacteria to ants.GigaScience · 2026Article
- The green lacewing venom system and the complex mechanisms underlying its evolution.Molecular biology and evolution · 2026Article
- A review of the venom microbiome and its utility in ecology and evolution including future directions for emerging research.Symbiosis (Philadelphia, Pa.) · 2025Article
- Genomic evidence for the widespread presence of GH45 cellulases among soil invertebrates.Molecular ecology · 2024Article
- Divergent venom effectors correlate with ecological niche in neuropteran predators.Communications biology · 2024Article
- The venom and telopodal defence systems of the centipede Lithobius forficatus are functionally convergent serial homologues.BMC biology · 2024Article
- Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae).Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Animals evoking fear in the Cradle of Humankind: snakes, scorpions, and large carnivores.Die Naturwissenschaften · 2023Article
- A bivalent remipede toxin promotes calcium release via ryanodine receptor activation.Nature communications · 2023Article
- Bioactive Peptides and Proteins from Centipede Venoms.Molecules (Basel, Switzerland) · 2022Review
- Centipede Venom: A Potential Source of Ion Channel Modulators.International journal of molecular sciences · 2022Review
- Myriapod genomes reveal ancestral horizontal gene transfer and hormonal gene loss in millipedes.Nature communications · 2022Article
- Evolution, Expression Patterns, and Distribution of Novel Ribbon Worm Predatory and Defensive Toxins.Molecular biology and evolution · 2022Article
- Horizontally Acquired Cellulases Assist the Expansion of Dietary Range in Pristionchus Nematodes.Molecular biology and evolution · 2022Article
- The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function.Toxins · 2021Review
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venoms have evolved over a hundred times in animals. Venom toxins are thought to evolve mostly by recruitment of endogenous proteins with physiological functions. Here we report phylogenetic analyses of venom proteome-annotated venom gland transcriptome data, assisted by genomic analyses, to show that centipede venoms have recruited at least five gene families from bacterial and fungal donors, involving at least eight horizontal gene transfer events. These results establish centipedes as currently the only known animals with venoms used in predation and defence that contain multiple gene families derived from horizontal gene transfer. The results also provide the first evidence for the implication of horizontal gene transfer in the evolutionary origin of venom in an animal lineage. Three of the bacterial gene families encode virulence factors, suggesting that horizontal gene transfer can provide a fast track channel for the evolution of novelty by the exaptation of bacterial weapons into animal venoms.
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