Evidence map›Paper›PMID 33547271›Full record

ReviewInternational journal of oral science2021

FACEts of mechanical regulation in the morphogenesis of craniofacial structures.

Wei Du, Arshia Bhojwani, Jimmy K Hu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of oral science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. The role of Rho GTPases in facial morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Review
  2. Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026
    Review
  3. Article
  4. How nature discovers rare Turing islands: Exploration by common limit cycles.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Three-dimensional cellular dynamics and mandibular morphogenesis.Frontiers in cell and developmental biology · 2026
    Article
  7. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Wei DuState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Arshia BhojwaniSchool of Dentistry, University of California Los Angeles, Los Angeles, CA, USA.
Jimmy K HuSchool of Dentistry, University of California Los Angeles, Los Angeles, CA, USA. jkhu@ucla.edu.ORCID http://orcid.org/0000-0003-1035-0779
University of California, Los Angeles · US

Funding

An investigation of the roles of mechanical signaling in YAP-mediated tooth renewR00DE025874 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HU, JIMMY KUANG-HSIEN · 2019 to 2021
$747k
NIDCR NIH HHS R00 DE025874U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R00DE025874
6 · The paper itself

Abstract

During embryonic development, organs undergo distinct and programmed morphological changes as they develop into their functional forms. While genetics and biochemical signals are well recognized regulators of morphogenesis, mechanical forces and the physical properties of tissues are now emerging as integral parts of this process as well. These physical factors drive coordinated cell movements and reorganizations, shape and size changes, proliferation and differentiation, as well as gene expression changes, and ultimately sculpt any developing structure by guiding correct cellular architectures and compositions. In this review we focus on several craniofacial structures, including the tooth, the mandible, the palate, and the cranium. We discuss the spatiotemporal regulation of different mechanical cues at both the cellular and tissue scales during craniofacial development and examine how tissue mechanics control various aspects of cell biology and signaling to shape a developing craniofacial organ.

Indexed as

SkullToothCell DifferentiationMorphogenesisSignal Transduction

Identifiers

PMID33547271
PMCPMC7865003
OpenAlexW3127119425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.