ReviewRMD open2021
To move or not to move: the paradoxical effect of physical exercise in axial spondyloarthritis.
Review in RMD open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Effects of high-intensity interval training on patients with inflammatory arthritis: a systematic review.BMC rheumatology · 2025Pooled it
- One-year effectiveness of long-term exercise therapy in people with axial spondyloarthritis and severe functional limitations.Rheumatology (Oxford, England) · 2025Trial
- Influence of sacroiliac joint variation on clinical features of axial spondyloarthritis: a comparative analysis.RMD open · 2025Trial
- Maximal strength training in patients with inflammatory rheumatic disease: implications for physical function and quality of life.European journal of applied physiology · 2022Trial
- Smartphone-Assisted High-Intensity Interval Training in Inflammatory Rheumatic Disease Patients: Randomized Controlled Trial.JMIR mHealth and uHealth · 2021Trial
- Clinical-psychosocial archetypes predict short-term outcomes in inflammatory arthritis: an unsupervised segmentation study.Clinical rheumatology · 2026Observational
- Rehabilitation modalities in ankylosing spondylitis: orthopaedic perspectives on function, bone health, and surgical safety.Journal of orthopaedics · 2026Review
- Inflammation and pain as interconnected targets in axial spondyloarthritis.Nature reviews. Rheumatology · 2026Review
- Age-related prevalence of sacroiliac joint variations and their association with structural damage in axial spondyloarthritis.BMC musculoskeletal disorders · 2026Article
- Article
- Physical Activity for Human and Planetary Health: Incorporating Green Exercise in the Management of Rheumatic Disease.Rheumatic diseases clinics of North America · 2026Review
- Inflammatory biomarkers in axial spondyloarthritis and the effect of moderate and high-intensity interval training - a narrative review.Molecular biology reports · 2025Review
- Effects of a Digital Functional Exercise Program on the Disease Activities and Physical Capabilities of Patients With Ankylosing Spondylitis: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Is there an anti-inflammatory effect of aerobic exercises on axial spondyloarthropathy patients? A prospective, randomized-controlled trial.Archives of rheumatology · 2025Article
- Personalized physical activity recommendations for people with axial spondyloarthritis using wearable activity tracker data: an exploratory study.Rheumatology international · 2025Article
- Literature review of non-pharmacological treatment for patients with axial spondyloarthritis.The Korean journal of internal medicine · 2025Review
- Physical fitness in adolescent patients with familial Mediterranean fever.Rheumatology international · 2024Article
- Patient journey, disease burden, and functional disability in patients with axial spondyloarthritis in South Africa: results of International Map of Axial Spondyloarthritis (IMAS).Clinical rheumatology · 2024Article
- Disrupted Neural Regeneration in Dry Eye Secondary to Ankylosing Spondylitis-With a Theoretical Link between Piezo2 Channelopathy and Gateway Reflex, WDR Neurons, and Flare-Ups.International journal of molecular sciences · 2023Article
- The Effects of Pilates Exercise Training Combined with Walking on Cardiorespiratory Fitness, Functional Capacity, and Disease Activity in Patients with Non-Radiologically Confirmed Axial Spondylitis.Journal of functional morphology and kinesiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last years, new researches focused on the role of biomechanical stress and microdamage in the pathogenesis of inflammatory arthritis and, in particular, in axial spondyloarthritis (axSpA). Animal models showed how entheseal stress and physical exercise could contribute to the development of inflammation and new bone formation at entheseal and articular sites, by activating innate immune system and the release of cytokines. Furthermore, clues of the involvement of biomechanical stress in the development of axSpA are present in clinical experiences. However, rehabilitation and exercise programmes are the cornerstone of treatment for axSpA, reducing disease activity and improving spinal function and quality of life. The concept of mechanical stress as a contributor to disease development and progression represents, potentially, a conceptual challenge for this approach. The aim of this review is to discuss the current evidence on the intriguing contribution of the biomechanical stress to the pathogenesis of inflammation and new bone formation and to evaluate and reflect on the role of exercise in the treatment and in the management of the disease, considering both the beneficial effects and its possible paradoxical action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.