Evidence map›Paper›PMID 33547203›Full record

ReviewDevelopment (Cambridge, England)2021

Cellular plasticity at the nexus of development and disease.

Lillian B Spatz, Ramon U Jin, Jason C Mills

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Evidence that injury can causebioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lillian B SpatzDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0003-3409-5880
Ramon U JinDivision of Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0001-7805-5800
Jason C MillsDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA jmills@wustl.edu.ORCID 0000-0002-0402-4662

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8M
PRE-AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGYT32HL007088 · NHLBI · WASHINGTON UNIVERSITY · PI Grant Anthony Challen, Stephen Oh · 1985 to 2026
$14.1M
Whole Exome Approaches for Esophageal Adenocarcinoma Susceptibility GenesU54CA163060 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI CHAK, AMITABH, GUDA, KISHORE · 2011 to 2022
$14.0M
REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1M
MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
MECHANISMS OF CHIEF CELL DEDIFFERENTIATIONR01DK105129 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2015 to 2026
$5.4M
The Role of EBI3 in Regulating Gastritis and Gastric CarcinogenesisR01DK110406 · NIDDK · SAINT LOUIS UNIVERSITY · PI DIPAOLO, RICHARD J · 2016 to 2020
$2.3M
Mechanisms Governing Expansion of Embryonic Progenitor Cells (EPCs) inMetaplasiaR01CA239645 · NCI · WASHINGTON UNIVERSITY · PI MILLS, JASON C · 2020 to 2024
$2.1M
Mechanisms and biomarkers in aberrant paligenosis-induced stomach tumorigenesisR01CA246208 · NCI · WASHINGTON UNIVERSITY · PI MILLS, JASON C · 2020 to 2024
$998k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA239645NCI NIH HHS R01 CA246208NCI NIH HHS T32 CA113275NCI NIH HHS U54 CA163060NHLBI NIH HHS T32 HL007088NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK094989NIDDK NIH HHS R01 DK105129NIDDK NIH HHS R01 DK110406
6 · The paper itself

Abstract

In October 2020, the Keystone Symposia Global Health Series hosted a Keystone eSymposia entitled 'Tissue Plasticity: Preservation and Alteration of Cellular Identity'. The event synthesized groundbreaking research from unusually diverse fields of study, presented in various formats, including live and virtual talks, panel discussions and interactive e-poster sessions. The meeting focused on cell identity changes and plasticity in multiple tissues, species and developmental contexts, both in homeostasis and during injury. Here, we review the key themes of the meeting: (1) cell-extrinsic drivers of plasticity; (2) epigenomic regulation of cell plasticity; and (3) conserved mechanisms governing plasticity. A salient take-home conclusion was that there may be conserved mechanisms used by cells to execute plasticity, with autodegradative activity (autophagy and lysosomes) playing a crucial initial step in diverse organs and organisms.

Indexed as

AnimalsCell PlasticityCell TransdifferentiationCellular ReprogrammingHomeostasisHumansMetaplasiaResin CementsNexusResin CementsDedifferentiationMetaplasiaPaligenosisReprogrammingTransdifferentiation

Identifiers

PMID33547203
PMCPMC12833736

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.