Evidence map›Paper›PMID 33547171›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production.

Yulia Kushnareva, Ian T Mathews, Alexander Y Andreyev, Gokmen Altay, Cecilia S Lindestam Arlehamn, Vijayanand Pandurangan, Roland Nilsson, Mohit Jain, Alessandro Sette, Bjoern Peters and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Yulia KushnarevaLa Jolla Institute for Immunology, La Jolla, CA 92037.
Ian T MathewsLa Jolla Institute for Immunology, La Jolla, CA 92037.ORCID 0000-0003-4773-7985
Alexander Y AndreyevDepartment of Pharmacology, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-9246-9943
Gokmen AltayLa Jolla Institute for Immunology, La Jolla, CA 92037.
Cecilia S Lindestam ArlehamnLa Jolla Institute for Immunology, La Jolla, CA 92037.ORCID 0000-0001-7302-8002
Vijayanand PanduranganLa Jolla Institute for Immunology, La Jolla, CA 92037.
Roland NilssonKarolinska Institutet, SE-171 76 Stockholm, Sweden.ORCID 0000-0002-6020-7498
Mohit JainDepartment of Pharmacology, University of California San Diego, La Jolla, CA 92093.
Alessandro SetteLa Jolla Institute for Immunology, La Jolla, CA 92037.
Bjoern PetersLa Jolla Institute for Immunology, La Jolla, CA 92037.
Sonia SharmaLa Jolla Institute for Immunology, La Jolla, CA 92037; soniasharma@lji.org.ORCID 0000-0002-6556-1963
La Jolla Institute for Immunology · USKarolinska Institutet · SEScripps Research Institute · USUniversity of California San Diego · US

Funding

Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogensU19AI118626 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2015 to 2026
$36.7M
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2U54CA260591 · NCI · CEDARS-SINAI MEDICAL CENTER · PI FIGUEIREDO, JANE C., KARIN, MICHAEL · 2020 to 2024
$9.1M
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, CHENG, SUSAN · 2020 to 2024
$8.7M
Stimulating Neo-Antigen Specific T Cell Responses in Head and Neck CancersU01DE028227 · NIDCR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GUTKIND, JORGE SILVIO, RAO, ANJANA · 2018 to 2022
$4.6M
Mapping the Plasma Exposome and its Association with Human Cardiovascular DiseaseR01ES027595 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, MOHIT · 2017 to 2021
$3.3M
Vaccine Induced Immune-Inflammatory Response and Cardiovascular RiskR01HL151828 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHENG, SUSAN · 2021 to 2024
$3.0M
Targeting tumor endothelium for cancer surveillance and immunotherapyR01CA199376 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SHARMA, SONIA · 2015 to 2019
$2.0M
RapidFire mass spectrometry systemS10OD020025 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAIN, MOHIT · 2015 to 2015
$600k
Small Molecule Metabolites as Predictors and Mediators of Immune Checkpoint Inhibitor ResponseF31CA236405 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI MATHEWS, IAN T. · 2019 to 2020
$68k
NCI NIH HHS F31 CA236405NCI NIH HHS R01 CA199376NCI NIH HHS U54 CA260591NHLBI NIH HHS R01 HL151828NIAID NIH HHS U19 AI118626NIA NIH HHS U54 AG065141NIDCR NIH HHS U01 DE028227NIEHS NIH HHS R01 ES027595NIGMS NIH HHS T32 GM007752NIH HHS S10 OD020025
6 · The paper itself

Abstract

CCR6

Indexed as

Gene Expression RegulationGene Knockdown TechniquesHealthy VolunteersHEK293 CellsHumansHydrolasesImmunologic MemoryInterferon-gammaInterleukin-17Primary Cell CulturePyrimidinesRNA, Small InterferingSignal TransductionTh1 CellsHydrolasesIFNG protein, humanInterferon-gammaInterleukin-17ISOC1 protein, humanPyrimidinesRNA, Small Interfering

Identifiers

PMID33547171
PMCPMC7946769
OpenAlexW3128988784

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.