ArticleScience advances2021
Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model.Nature communications · 2026Article
- Distinct contributions of two subpopulations of subthalamic neurons to levodopa-induced dyskinesia.Science advances · 2026Article
- The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026Article
- Article
- The Parafascicular Role in Updating Action from a Spatial to a Visual Strategy Is Driven by Its Glutamatergic Mesencephalic Locomotor Region Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The parafascicular nucleus of the thalamus orchestrates coordinated skeletomotor, autonomic, and aversive state transitions.bioRxiv : the preprint server for biology · 2026Article
- Article
- Microstructural alterations of parafascicular nucleus pathways associated with freezing of gait in Parkinson's disease.Brain communications · 2026Article
- Dissociable roles of distinct thalamic circuits in learning reaches to spatial targets.Nature communications · 2025Article
- Article
- Movement-related increases in subthalamic activity optimize locomotion.Cell reports · 2024Article
- Pathways from the Superior Colliculus to the Basal Ganglia.Current neuropharmacology · 2024Review
- Is there room in epilepsy for the claustrum?Frontiers in systems biology · 2024Article
- Functional brain controllability in Parkinson's disease and its association with motor outcomes after deep brain stimulation.Frontiers in neuroscience · 2024Article
- Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease.Translational neurodegeneration · 2023Review
- Selective Activation of Subthalamic Nucleus Output Quantitatively Scales Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The role of the parafascicular thalamic nucleus in action initiation and steering.Current biology : CB · 2023Article
- Circuit dysfunctions of associative and sensorimotor basal ganglia loops in alcohol use disorder: insights from animal models.Addiction neuroscience · 2023Article
- Color-Coding Method Reveals Enhancement of Stereotypic Locomotion by Phenazepam in Rat Open Field Test.Brain sciences · 2023Article
- Micropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs.Frontiers in neuroanatomy · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
The parafascicular nucleus (Pf) of the thalamus provides major projections to the basal ganglia, a set of subcortical nuclei involved in action initiation. Here, we show that Pf projections to the subthalamic nucleus (STN), but not to the striatum, are responsible for movement initiation. Because the STN is a major target of deep brain stimulation treatments for Parkinson's disease, we tested the effect of selective stimulation of Pf-STN projections in a mouse model of PD. Bilateral dopamine depletion with 6-OHDA created complete akinesia in mice, but Pf-STN stimulation immediately and markedly restored a variety of natural behaviors. Our results therefore revealed a functionally novel neural pathway for the initiation of movements that can be recruited to rescue movement deficits after dopamine depletion. They not only shed light on the clinical efficacy of conventional STN DBS but also suggest more selective and improved stimulation strategies for the treatment of parkinsonian symptoms.
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