ArticleScience advances2021
Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
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Who cites it
55 citing papers in PubMed, 83 citations in OpenAlex.
- Nitric Oxide in the Intestinal Stem Cell Niche: A Spatial Model of Nitrosative Stress and Clonal Evolution in Colitis-Associated Colorectal Cancer.Digestive diseases and sciences · 2026Review
- PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification.Circulation · 2026Article
- Mechanisms, precision therapies, and technological frontiers in coronary atherosclerosis: a comprehensive review.Acta pharmacologica Sinica · 2026Review
- A novel antisense lncRNA, LPCRL, functions as a molecular scaffold for the USP15/MIB1 complex to promote primary cisplatin resistance and tumor progression in lung squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2026Article
- Cyclic guanosine monophosphate-protein kinase G signaling attenuates aortic valve calcification through ULK1-mediated autophagy.Signal transduction and targeted therapy · 2026Article
- Bilayer vascular grafts separately loaded with sodium copper chlorophyllin and keratin-based hydrogen sulfide donor with pro-endothelialization, anti-thrombogenicity, anti-inflammation, and anti-calcification properties.Bioactive materials · 2026Article
- Endothelial USP8 is essential for angiogenesis.Angiogenesis · 2026Article
- Expression of Netrin-1 in the developing mouse heart.Gene expression patterns : GEP · 2025Article
- The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nitric oxide‑mediated S‑Nitrosylation contributes to signaling transduction in human physiological and pathological status (Review).International journal of molecular medicine · 2025Review
- A Transcriptomic Approach to Sex Differences in Calcific Aortic Valve Stenosis in Patients with a Tricuspid Aortic Valve.CJC open · 2025Article
- Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling.JACC. Basic to translational science · 2025Article
- Navigating the Landscape of Translational Medicine of Calcific Aortic Valve Disease: Bridging Bench to Bedside.JACC. Asia · 2025Review
- Establishment and characterization of a novel immortalized human aortic valve interstitial cell line.Scientific reports · 2025Article
- Ubiquitin-specific protease: an emerging key player in cardiomyopathy.Cell communication and signaling : CCS · 2025Review
- ACAA2 Protects Against Cardiac Dysfunction and Lipid Peroxidation in Renal Insufficiency with the Treatment of S-Nitroso-L-Cysteine.Biomolecules · 2025Article
- Calcific aortic stenosis: omics-based target discovery and therapy development.European heart journal · 2025Review
- Communication between endothelial cells and osteoblasts in regulation of bone homeostasis: Notch players.Stem cell research & therapy · 2025Review
- Decreased METTL3 in atrial myocytes promotes atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Atherosclerosis, calcific aortic valve disease and mitral annular calcification: same or different?International journal of cardiology · 2025Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Uddalak MajumdarCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0001-6098-2366
Sathiyanarayanan ManivannanCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-9470-2390
Madhumita BasuCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-0378-7780
Yukie UeyamaCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA.
Mark C BlaserDivision of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3923-9786
Emily CameronCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0001-7217-7364
Michael R McDermottCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA.
Joy LincolnDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Susan E ColeDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-7063-9593
Stephen WoodGriffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia.ORCID 0000-0002-2576-7457
Elena AikawaDivision of Cardiovascular Medicine, Department of Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7835-2135
Brenda LillyCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA.
Vidu GargCenter for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH, USA. vidu.garg@nationwidechildrens.org.ORCID 0000-0002-3778-5927
Nationwide Children's Hospital · USBrigham and Women's Hospital · USChildren's Hospital of Wisconsin · USGriffith University · AUThe Ohio State University · US
Funding
Improving Mitral Compensation In Ischemic RegurgitationR01HL141917 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AIKAWA, ELENA, BISCHOFF, JOYCE E. · 2018 to 2021
$5.6MMacrophage-derived microcalcificaitonsR01HL136431 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2017 to 2020
$2.7MThe Role of Notch in Calcific Aortic Valve DiseaseR01HL132801 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU, LILLY, BRENDA J · 2016 to 2019
$2.6MTraining in Congenital and Acquired Heart DiseaseT32HL098039 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU, MOHLER, PETER J. · 2009 to 2019
$2.5MNew driver of fibrosis and calcification in CAVDR01HL147095 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2019 to 2022
$2.4MMedical Therapies in the Treatment of Calcific Aortic Valve DiseaseR01HL142685 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LINCOLN, JOY · 2018 to 2022
$2.2MMolecular Mechanisms of Aortic Valve FormationR01HL121797 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GARG, VIDU · 2015 to 2018
$1.6MNHLBI NIH HHS R01 HL121797NHLBI NIH HHS R01 HL132801NHLBI NIH HHS R01 HL136431NHLBI NIH HHS R01 HL141917NHLBI NIH HHS R01 HL142685NHLBI NIH HHS R01 HL147095NHLBI NIH HHS T32 HL098039
Abstract
Calcific aortic valve disease (CAVD) is an increasingly prevalent condition, and endothelial dysfunction is implicated in its etiology. We previously identified nitric oxide (NO) as a calcification inhibitor by its activation of
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