ArticleScience advances2021
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 100 papers, 1 of them a synthesis that pooled it.
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100citing papers in PubMed, 1 pooled it
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.Nature medicine · 2022Pooled it
- High-Risk Rhabdomyosarcomas Feature a Convergent Cell State.Cancer research · 2026Article
- Review
- Human and mouse adrenal glands are characterized by species-specific steroidogenic states and tissue turnover.Nature genetics · 2026Article
- Single-cell and spatial omics reveals region-specific plasticity and therapeutic vulnerabilities in metastatic high-risk neuroblastoma.Science advances · 2026Article
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- Quantum mechanics-based multitensor AI/ML uniquely able to discover, validate, and interpret predictors from small-cohort noisy high-dimensional multiomic data.APL quantum · 2026Article
- A Comparative Single-Cell Atlas Reveals Pre-injury Signatures of Superior Healing in Oral Mucosa and Informing a New Paradigm for Wound Management.Functional & integrative genomics · 2026Article
- YAP1 Enhances Mesenchymal-Type Gene Expression in Human Adrenergic-Type Neuroblastoma Cells.Cancers · 2026Article
- Review
- Single-Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A non-canonical lymphoblast in refractory childhood T-cell leukaemia.Nature communications · 2025Article
- HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chromosomal instability degrades developmental phenotypes essential for anti-GD2 immunotherapy outcomes in high-risk neuroblastoma.Cell reports. Medicine · 2025Article
- Single-cell and Spatial Omics Reveals Region-Specific Plasticity and Therapeutic Vulnerabilities in Metastatic High-Risk Neuroblastoma.bioRxiv : the preprint server for biology · 2025Article
- Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers.Cancer discovery · 2025Article
- RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity.Nature communications · 2025Article
- Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Integrative single-cell and bulk transcriptomic analyses identify a robust four-gene signature for risk stratification in neuroblastoma.Translational cancer research · 2025Article
- Single-Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
39 authors.
Gerda KildisiuteWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0002-5314-2294
Waleed M KholosyPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.ORCID 0000-0002-7910-6419
Matthew D YoungWellcome Sanger Institute, CB10 1SA Hinxton, UK. my4@sanger.ac.uk k.straathof@ucl.ac.uk j.j.molenaar@prinsesmaximacentrum.nl sb31@sanger.ac.uk.ORCID 0000-0003-0937-5290
Kenny RobertsWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0001-6155-0821
Rasa ElmentaiteWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0001-7366-5466
Sander R van HooffPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.
Clarissa N PacynaWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0002-4404-8183
Eleonora KhabirovaWellcome Sanger Institute, CB10 1SA Hinxton, UK.
Alice PiapiUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK.
Christine ThevanesanUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK.ORCID 0000-0001-6996-1545
Eva Bugallo-BlancoUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK.ORCID 0000-0002-4350-0625
Christina BurkeUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK.ORCID 0000-0001-5381-3185
Lira MamanovaWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0003-1463-8622
Kaylee M KellerPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.
Karin P S Langenberg-VervergaertPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.ORCID 0000-0002-6780-0585
Philip LijnzaadPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.ORCID 0000-0002-7535-583X
Thanasis MargaritisPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.ORCID 0000-0003-4040-2015
Frank C P HolstegePrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.ORCID 0000-0002-8090-5146
Michelle L TasPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.ORCID 0000-0002-4585-5411
Marc H W A WijnenPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.
Max M van NoeselPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.
Ignacio Del ValleUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK.ORCID 0000-0003-2595-3652
Giuseppe BaroneGreat Ormond Street Hospital for Children (GOSH), NHS Foundation Trust, NIHR Great Ormond Street Hospital Biomedical Research Centre, WC1N 3JH London, UK.ORCID 0000-0003-3264-1913
Reinier van der LindenHubrecht Institute, KNAW, 3584 CT Utrecht, Netherlands.ORCID 0000-0001-7437-8901
Catriona DuncanGreat Ormond Street Hospital for Children (GOSH), NHS Foundation Trust, NIHR Great Ormond Street Hospital Biomedical Research Centre, WC1N 3JH London, UK.ORCID 0000-0002-9496-4745
John AndersonUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK.ORCID 0000-0001-7509-3203
John C AchermannUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK.ORCID 0000-0001-8787-6272
Muzlifah HaniffaWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0002-3927-2084
Sarah A TeichmannWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0002-6294-6366
Dyanne RamplingGreat Ormond Street Hospital for Children (GOSH), NHS Foundation Trust, NIHR Great Ormond Street Hospital Biomedical Research Centre, WC1N 3JH London, UK.ORCID 0000-0003-3508-8404
Neil J SebireGreat Ormond Street Hospital for Children (GOSH), NHS Foundation Trust, NIHR Great Ormond Street Hospital Biomedical Research Centre, WC1N 3JH London, UK.ORCID 0000-0001-5348-9063
Xiaoling HeMRC-WT Cambridge Stem Cell Institute, University of Cambridge, CB2 0QQ Cambridge, UK.
Ronald R de KrijgerPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands.
Roger A BarkerMRC-WT Cambridge Stem Cell Institute, University of Cambridge, CB2 0QQ Cambridge, UK.ORCID 0000-0001-8843-7730
Kerstin B MeyerWellcome Sanger Institute, CB10 1SA Hinxton, UK.ORCID 0000-0001-5906-1498
Omer BayraktarWellcome Sanger Institute, CB10 1SA Hinxton, UK.
Karin StraathofUCL Great Ormond Street Institute of Child Health, WC1N 1EH London, UK. my4@sanger.ac.uk k.straathof@ucl.ac.uk j.j.molenaar@prinsesmaximacentrum.nl sb31@sanger.ac.uk.ORCID 0000-0001-9673-8568
Jan J MolenaarPrincess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, Netherlands. my4@sanger.ac.uk k.straathof@ucl.ac.uk j.j.molenaar@prinsesmaximacentrum.nl sb31@sanger.ac.uk.ORCID 0000-0002-2007-0431
Sam BehjatiWellcome Sanger Institute, CB10 1SA Hinxton, UK. my4@sanger.ac.uk k.straathof@ucl.ac.uk j.j.molenaar@prinsesmaximacentrum.nl sb31@sanger.ac.uk.ORCID 0000-0002-6600-7665
Funding
Medical Research Council MC_PC_17230
Abstract
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cells by comparing cancer (
Indexed as
Neural Stem CellsNeuroblastomaChildHumansNeural CrestRNA, MessengerTranscriptomeRNA, Messenger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.