Observational studyThe British journal of ophthalmology2022
Low fraction of fetal haemoglobin is associated with retinopathy of prematurity in the very preterm infant.
Observational study in The British journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Controlled Intervention, Multi-centre Study Aiming to Preserve Blood Factors Using Micro-methods to Improve Development in Extremely Preterm Infants - "Less is More"
Correlation Between Hyperbilirubinemia and Retinopathy of Prematurity in Preterm Infants of Very Low Birth Weight and Less Than 32 Weeks Gestational Age: a Retrospective Study
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Minimizing blood sampling in preterm infants.The Cochrane database of systematic reviews · 2026Pooled it
- Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial.Italian journal of pediatrics · 2024Trial
- Differences in Cerebral Tissue Oxygenation in Preterm Neonates Receiving Adult or Cord Blood Red Blood Cell Transfusions.JAMA network open · 2023Trial
- Trial
- Establishing reference intervals for fetal hemoglobin percentage from 23 to 40 weeks of gestation using refineR.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Assessment of iron sufficiency in premature infants treated with darbepoetin using conventional and novel erythrocyte metrics.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Development and production of allogeneic cord blood-derived red blood cell concentrates for transfusion to extremely preterm neonates, the All-Cord study.Transfusion · 2026Article
- A CBC drawn postnatally from umbilical cord blood can provide valuable diagnostic information for infants admitted to the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Decreasing packed red blood cell (pRBC) transfusions in neonates through quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Ten-year changes in risk factors for requiring treatment of retinopathy of prematurity in extremely low birth weight infants: a multicenter study in Tokyo.Japanese journal of ophthalmology · 2026Observational
- Transfusion Histories of Neonates Who Developed Severe Retinopathy of Prematurity.Neonatology · 2026Article
- Acoustofluidic Plasmapheresis System Designed for Ultralow Blood Volume Applications.Analytical chemistry · 2026Article
- Changes in Fetal Hemoglobin in Very Preterm Infants Born Small for Gestational Age: A Retrospective Observational Study.Children (Basel, Switzerland) · 2026Article
- The oxygen paradox in retinopathy of prematurity: could fetal hemoglobin be the key?Frontiers in pediatrics · 2026Article
- Systematic review and meta-analysis of risk prediction models for retinopathy of prematurity in preterm infants.Biomedical reports · 2025Article
- The association between red blood cell transfusion timing and the development of retinopathy of prematurity: Application of the two-phase theory.Acta ophthalmologica · 2025Article
- Cord red blood cell transfusions for severe retinopathy in preterm neonates in Italy: a multicenter randomized controlled trial.EClinicalMedicine · 2025Article
- Fetal Hemoglobin in Preterm Infants After Resuscitation with Immediate Cord Clamping, Delayed Cord Clamping, or Cord Milking.Children (Basel, Switzerland) · 2025Article
- Fetal haemoglobin and oxygen requirement in preterm infants: an observational study.Archives of disease in childhood. Fetal and neonatal edition · 2025Observational
- [Progress in the clinical application of cord blood transfusion in neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood loss and adult blood transfusions are common during the neonatal period in preterm infants. The objective of the study was to clarify if degree of loss of fetal haemoglobin (HbF) was associated with later retinopathy of prematurity (ROP).
methodsRetrospective observational cohort study. In total, 452 infants born <30 gestational weeks at a tertiary level neonatal intensive care unit in Sweden in 2009-2015 were included, 385 of whom had final ROP outcome. Mean fractions of HbF (%) during the first postnatal week were calculated from 11 861 arterial blood gas analyses. The relationship between fractions of HbF (%) and ROP was evaluated.
resultsThe mean (SD) gestational age (GA) at birth was 26.4 (1.8) weeks. In total, 104 (27 %) infants developed ROP. Higher fraction of HbF (%) was associated with a lower prevalence of ROP, OR by a 10% increase 0.83 (95% CI: 0.71 to 0.97; p=0.019), following adjustment for GA at birth, small for GA and sex. Infants with HbF (%) in the lowest quartile had OR of 22.0 (95% CI: 8.1 to 59.2; p<0.001) for ROP development compared with those in the highest quartile. The predictive ability (area under the curve) of HbF (%) in the full model during the first week was 0.849 for ROP.
conclusionsEarly low fraction of HbF is independently associated with abnormal retinal neurovascular development in the very preterm infant. The potential benefit of minimising blood loss on development of ROP will be investigated in a multicenter randomised trial (NCT04239690).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.