Evidence map›Paper›PMID 33546973›Full record

ReviewTrends in cognitive sciences2021

Toward Studying Cognition in a Dish.

Nicolas Rouleau, Nirosha J Murugan, David L Kaplan

Open access · greenAbstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Vascularizing the brainiScience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Nicolas RouleauDepartment of Psychology, Algoma University, 1520 Queen Street East, Sault Ste. Marie, Ontario, Canada, P6A 2G4; Department of Biomedical Engineering, Tufts University, Science and Technology Center, 4 Colby Street, Medford, MA 02155, USA.
Nirosha J MuruganDepartment of Biology, Algoma University, 1520 Queen Street East, Sault Ste. Marie, Ontario, Canada, P6A 2G4.
David L KaplanDepartment of Biomedical Engineering, Tufts University, Science and Technology Center, 4 Colby Street, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.
Tufts University · USAlgoma University · CA

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
Functional three dimensional brain-like tissues to study mechanisms of traumatic brain injuryR01NS092847 · NINDS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2015 to 2019
$1.8M
NIBIB NIH HHS P41 EB027062NINDS NIH HHS R01 NS092847
6 · The paper itself

Abstract

Bioengineered neural tissues help advance our understanding of neurodevelopment, regeneration, and neural disease; however, it remains unclear whether they can replicate higher-order functions including cognition. Building upon technical achievements in the fields of biomaterials, tissue engineering, and cell biology, investigators have generated an assortment of artificial brain structures and cocultured circuits. Though they have displayed basic electrochemical signaling, their capacities to generate minimal patterns of information processing suggestive of high-order cognitive analogues have not yet been explored. Here, we review the current state of neural tissue engineering and consider the possibility of a study of cognition in vitro. We adopt a practical definition of minimal cognition, anticipate problems of measurement, and discuss solutions toward a study of cognition in a dish.

Indexed as

BrainCognitionSignal Transductionbioengineeringinformation processingin vitrominimal cognitionneural tissue engineering

Identifiers

PMID33546973
PMCPMC7946736
OpenAlexW3127991229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.