SynthesisHealth and quality of life outcomes2021
A comparison of self-reported and proxy-reported health utilities in children: a systematic review and meta-analysis.
Synthesis in Health and quality of life outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Exploring the Use of Pictorial Approaches in the Development of Paediatric Patient-Reported Outcome Instruments: A Systematic Review.PharmacoEconomics · 2024Pooled it
- Quality appraisal for systematic literature reviews of health state utility values: a descriptive analysis.BMC medical research methodology · 2022Pooled it
- Are We Agreed? Self- Versus Proxy-Reporting of Paediatric Health-Related Quality of Life (HRQoL) Using Generic Preference-Based Measures: A Systematic Review and Meta-Analysis.PharmacoEconomics · 2022Pooled it
- Modeling Oxygen Saturation Targets, Mortality, and Retinopathy Among Extremely Preterm Infants.JAMA network open · 2026Article
- Instruments for measuring evidence-based practice ability of nursing students: a COSMIN-based systematic review.BMC nursing · 2026Article
- Parental presence is associated with parent-child agreement in quality of life assessment among 5- to 7-year-old children: a comparison of administration conditions using the Dutch PedsQL.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Impact of inactivated influenza vaccination on health-related quality of life for young children using Japanese experimental EuroQol toddler and infant populations (EQ-TIPS) v2.0.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Efficacy of gamified digital health interventions for children and adolescents with autism spectrum disorder: a systematic review and meta-analysis.Child and adolescent psychiatry and mental health · 2025Review
- Determining health-related quality of life among children with malaria in Kenya: does the choice of EQ-5D value set matter?Health and quality of life outcomes · 2025Article
- Validation of a parent-reported outcome measure for young boys with a condition affecting sex development (PRO-CSD).Archives of disease in childhood · 2025Article
- Proxy reporting in health: a scoping review of instructions, perspectives, and reporting experiences.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Psychometric analysis of the patient-reported outcomes measurement information system parent proxy physical function-upper extremity item bank for children with Duchenne muscular dystrophy.Frontiers in neurology · 2025Article
- Health-related quality of life and caregiver burden of pediatric patients with inborn errors of metabolism in Japan using EQ-5D-Y, PedsQL, and J-ZBI.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Daily functioning and (health-related) quality of life of young adult survivors of childhood bacterial meningitis.European journal of pediatrics · 2024Article
- Quality Appraisal in Systematic Literature Reviews of Studies Eliciting Health State Utility Values: Conceptual Considerations.PharmacoEconomics · 2024Article
- Meeting the Challenges of Preference-Weighted Health-Related Quality-of-Life Measurement in Children.PharmacoEconomics · 2024Article
- A Comparison of the Psychometric Properties of the EQ-5D-Y-3L and EQ-5D-Y-5L Using Paediatric Multi-Instrument Comparison (P-MIC) Study Data.PharmacoEconomics · 2024Article
- Health-related quality of life and subjective well-being among children aged 9-12 years in Shandong Province, China.Health and quality of life outcomes · 2024Article
- Estimating health state utilities in Duchenne muscular dystrophy using the health utilities index and EQ-5D-5L.Journal of patient-reported outcomes · 2023Article
- 'Like holding the axe on who should live or not': adolescents' and adults' perceptions of valuing children's health states using a standardised valuation protocol for the EQ-5D-Y-3L.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to conduct a systematic review and meta-analysis to compare differences in health utilities (HUs) assessed by self and proxy respondents in children, as well as to evaluate the effects of health conditions, valuation methods, and proxy types on the differences.
methodsEligible studies published in PubMed, Embase, Web of Science, and Cochrane Library up to December 2019 were identified according to PRISMA guidelines. Meta-analyses were performed to calculate the weighted mean differences (WMDs) in HUs between proxy- versus self-reports. Mixed-effects meta-regressions were applied to explore differences in WMDs among each health condition, valuation method and proxy type.
resultsA total of 30 studies were finally included, comprising 211 pairs of HUs assessed by 15,294 children and 16,103 proxies. This study identified 34 health conditions, 10 valuation methods, and 3 proxy types. In general, proxy-reported HUs were significantly different from those assessed by children themselves, while the direction and magnitude of these differences were inconsistent regarding health conditions, valuation methods, and proxy types. Meta-regression demonstrated that WMDs were significantly different in patients with ear diseases relative to the general population; in those measured by EQ-5D, Health utility index 2 (HUI2), and Pediatric asthma health outcome measure relative to Visual analogue scale method; while were not significantly different in individuals adopting clinician-proxy and caregiver-proxy relative to parent-proxy.
conclusionDivergence existed in HUs between self and proxy-reports. Our findings highlight the importance of selecting appropriate self and/or proxy-reported HUs in health-related quality of life measurement and economic evaluations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.